Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. [5] It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones (H2A, H2B, H3, and H4).

2024年12月25日 · HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Glioma Susceptibility 1 and Mood Disorder. Among its related pathways are RNA Polymerase I Promoter Opening and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly overexpressed in solid tumors. Nevertheless, transformed cells lacking HDAC2 due to …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles.

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD + -dependent mechanisms to …

The present review updates details on the structural features, physiological functions, and roles of HDAC2 in different types of cancer, emphasizing the challenges and status of the development of HDAC2 selective inhibitors against various types of cancer.

histone deacetylase 2, YY1-associated factor 1, protein deacylase HDAC2, transcriptional regulator homolog RPD3. HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4B. ACAP3 negatively regulated by HDAC2 inhibits the malignant development of papillary thyroid carcinoma cells.

Histone deacetylase 2 (HDAC2), a negative regulator of neuroplasticity, is up-regul … Environmental enrichment (EE) is a generally accepted strategy to promote stroke recovery and its beneficial effect is positively correlated with neuroplasticity.

2009年11月4日 · Histone deacetylases control cellular signaling and gene expression. Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly overexpressed in solid tumors.

2010年8月29日 · Here we identify the related human histone deacetylases HDAC1 and HDAC2 as two participants in the DNA-damage response. We show that acetylation of histone H3 Lys56 (H3K56) was regulated by HDAC1...