Metabotropic glutamate receptor 5 is an excitatory G q -coupled G protein-coupled receptor [5] predominantly expressed on the postsynaptic sites of neurons. [6] . In humans, it is encoded by the GRM5 gene. [7][8]

2024年12月25日 · GRM5 (Glutamate Metabotropic Receptor 5) is a Protein Coding gene. Diseases associated with GRM5 include Autism Spectrum Disorder and Central Nervous System Disease. Among its related pathways are GPCR downstream signalling and Protein-protein interactions at synapses.

gnificantly higher expression level in the metabotropic receptor genes GRM5 in Locus coeruleus neurons. Findings demonstrate a developmental regulation of mGluR5 in the hippocampus and suggest a role for this receptor in astrocytes during early …

Restricted expression toward brain (RPKM 10.2). 该基因编码 G 蛋白偶联受体 3 蛋白家族的成员。 编码的蛋白质是变嗜性谷氨酸受体，其信号激活磷脂酰肌醇-钙第二信使系统。 这种蛋白质可能参与神经网络活动和突触可塑性的调节。 谷氨酸能神经传递涉及正常大脑功能的大多数方面，并且在许多神经病理学状况下可能受到干扰。 已在 11 号染色体上定义了该基因的假基因。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 5 月] This gene encodes a member of the G …

2024年7月1日 · The GRM3, GRM5, and GRM7 proteins exhibited highly conserved domains according to protein domain analysis (Fig. 2A). The amino acid sequence alignments of the conserved domain also support this conclusion (SFig 1-4). Lr-GRM5 also shares a GluR_Homer-bdg domain, which is a feature shared by several orthologs of GRM5.

2025年2月8日 · Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [ [18]F]PSS232 PET/MRI study.

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Human chromosome 11 DNA sequence and analysis including novel gene identification. The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.

背景 代谢型谷氨酸受体亚型 5 (grm5) 调节细胞兴奋性和神经传递，并已被建议在包括帕金森病 (pd) 在内的几种神经精神和神经退行性疾病中发挥调节作用。

HGNC Approved Gene Symbol: GRM5. Cytogenetic location: 11q14.2-q14.3 Genomic coordinates (GRCh38) : 11:88,504,642-89,065,982 (from NCBI) L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.

GRM5 (coding for metabotropic glutamate receptor 5, mGluR5) is a promising target for the treatment of cognitive deficits in schizophrenia, but there has been little investigation of its association with cognitive and brain phenotypes within this disorder. We examined the effects of common genetic v …