GLS2 Gene - GeneCards | GLSL Protein | GLSL Antibody
2024年12月25日 · GLS2 (Glutaminase 2) is a Protein Coding gene. Diseases associated with GLS2 include Metabolic Acidosis and Juvenile Dermatitis Herpetiformis. Among its related …
GLS2 - Wikipedia
GLS2 is a part of the glutaminase family. The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric …
聊聊谷氨酰胺代谢与癌症的关系——Hallmark - 知乎
gls2是一个p53靶基因，p53能激活gls2表达，同时降低细胞内活性氧，保护细胞基因组免受损伤。 其他抑癌基因，如Rb和LKB1，通过E2F3抑制ASCT2的表达来影响谷氨酰胺的摄取。
谷氨酰胺代谢与癌症治疗 - 知乎 - 知乎专栏
肿瘤细胞过度激活了肾型谷氨酰胺酶(gls)，gls2主要作用于在非癌细胞，催化谷氨酰胺的代谢。 谷氨酰胺在细胞功能中的多效性作用，如能量合成、大分子合成、mTOR活化和活性氧平衡，使 …
Phosphate-activated glutaminase (GLS2), a p53-inducible …
2010年4月20日 · We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a key enzyme in conversion of glutamine to glutamate, and thereby a regulator of …
Mammalian Glutaminase Gls2 Gene Encodes Two Functional …
We demonstrate for the first time simultaneous expression of two transcript variants from the Gls2 gene in human, rat and mouse. A combination of RT-PCR, primer-extension analysis, …
【综述】| 谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进 …
2024年3月1日 · gls是一种线粒体酶，分为gls1和gls2两种亚型，gls1是一种线粒体基质蛋白，在转录阶段通过不同的剪切方式又可分为gac（肝型）和kag（肾型）两种亚型，gac只存在于线粒 …
GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in ...
2022年9月16日 · Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been previously implicated in activities consistent with tumor suppression. Here we generated Gls2 …
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in …
2019年10月1日 · Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has …
谷氨酰胺酶 2（GLS2）基因 | MCE - MCE-生物活性分子大师
The protein encoded by this gene is a mitochondrial phosphate-activated Glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. …