2013年12月23日 · If the elimination rate slows half-life increases. By taking GFJ with bupe you are inhibiting the liver enzymes responsible for its metabolism, meaning less drug per unit time is eliminated. Regarding dosing. If you are on super doses of bupe, you may require more GFJ because they basically compete for the enzymes involved in their metabolism.

2006年7月26日 · i havent noticed any potentiation with xanax and grapefruit juice in the past, actually the only benzo i found to be potentiated by gfj in my body is valium. there's studies to back this too. 8 - 12 oz of 100% gfj 30-45 min before valium is supposed to add an hour or so to the tmax (time to max concentration in the blood) and be up to 3 times stronger.

2010年10月26日 · Yeah, I mean I know people who very elaborately and methodically dose potentiators at specific intervals, like for example, taking tagamet 1 hour before, drinking grapefruit juice 45 minutes before, taking diphenhydramine and/or hydroxyzine 30 minutes before, more tagamet and more GFJ 15 minutes before, benzodiazepines, and finally, their ...

2008年10月13日 · And that's exactly why GFJ IS a fairly good potentiatior: as it inhibits CYP3A4 (the unwanted one when it comes to metabolizing Codeine into Morphine) , hence, when Codeine is converted , it will undergo the hepatic metabolism by mostly CYP2D6, resulting in more moprhine, an optimized conversion and a longer half-life(as it'll take more time to ...

2010年10月26日 · to get optimal results with GFJ, the user drinks multiple cups of GFJ. on the other hand, if you eat the actual grapefruit raw, has higher levels of bergamottin. the reason tagamet is effficient is because you can easily take 3-5 pills and get good inhibition, while with GFJ and grapefruits, you have to eat more to get the same effect.

2014年1月18日 · Personally when I used to try this the difference was negligible and didn't seem worth the cost of the Tagamet. GFJ however is delicious and is never a waste of your hard earned dollars. I've found dxm polistirex to potentiate almost everything my memory is hazy on whether it's worthwhile for benzos, but it certainly couldn't hurt.

2010年5月26日 · But also interestingly enough it says hepatic inhibition only occurs at higher doses (of GFJ). So perhaps the reason Clonazepam, and I assume then other nitro-substituted benzos are only weakly (if at all) affected by GFJ is that you simply need to ingest a lot of it to get hepatic inhibition.

2012年11月9日 · the acidity of gfj will not increase methadone breakdown, as methadone is stable to acid. if you take methadone with GFJ all the time, your body will become accustomed to the higher levels of methadone in your blood, and you will …

2010年4月13日 · Diazepam and alprazolam on the other hand - yes, to the point where I have to be careful to have one small glass or less. GFJ is a part of my diet aside from benzodiazepines, love the stuff But more than 1 glass, especially of white GFJ, and I notice a marked increase in sedation, amnesia, and motor impairment. In me, this is more pronounced w ...

2004年5月9日 · I've experienced a noted effect on MDMA and mushroom trips with GFJ, and those are processed by CYP2D6, yet GFJ is not a listed inhibitor of that enzyme. Just like there are polymorphisms in people's CYP450 genetics, I think there may also be a polymorphism in how the inhibitors are applied across the enzyme categories.