GDF5 is expressed in the developing central nervous system, [8] and has a role in skeletal and joint development. [9] [10] [11] It also increases the survival of neurones that respond to the …

2024年12月25日 · GDF5 (Growth Differentiation Factor 5) is a Protein Coding gene. Diseases associated with GDF5 include Brachydactyly, Type C and Brachydactyly, Type A2. Among its …

GDF5 regulates TGF-beta-dependent angiogenesis in breast carcinoma cells. Growth differentiation factor 5 modulation of chondrogenesis of self-assembled constructs involves …

2020年1月13日 · Our findings suggest that Gdf5 upregulation in articular cartilage and synovium is a generic response to knee injury that is dependent on downstream regulatory sequence …

Growth/differentiation factor 5 gene (GDF5; OMIM * 601146) has a cytogenetic location of 20q11.22 and encodes the growth/differentiation factor 5 protein. GDF5 is a TGF-beta …

Growth differentiation factor 5 (GDF5) is a member of the bone morphogenic protein (BMP) family and plays critical roles in organ development processes including bone, cartilage, ligament, …

2021年6月7日 · Viral overexpression of growth/differentiation factor 5 (GDF5) in the substantia nigra protects dopaminergic neurons and their striatal terminals against α-synuclein-induced …

Growth/differentiation factor-5 (GDF5) is a member of the transforming growth factor-β superfamily which has potent effects on dopaminergic neurones in vitro and in vivo. GDF5 is …

Being the best studied skeletal locus, GDF5 associates with many diseases and has a complex cis-regulatory architecture. We interrogate GDF5 regulatory interactions and model disease …

2016年6月21日 · Here, we provide evidence that joints develop through a continuous influx of cells into the interzone, where they contribute differentially to forming joint tissues. Using a …