Gastrulation Brain Homeobox 2 (GBX2) is a homeobox gene involved in the normal development of rhombomeres 1-3 which is the mid/hindbrain region. This gene is a dosage dependent transcription factor involved in the regulation of proper expression of other genes.

2024年12月25日 · GBX2 (Gastrulation Brain Homeobox 2) is a Protein Coding gene. Diseases associated with GBX2 include Opitz Gbbb Syndrome and Charge Syndrome. Among its related pathways are Gastrulation and Nervous system development.

2013年11月1日 · Gbx2 functions as a transcriptional repressor in embryos and P19 cells. The Gbx subfamily of homeodomain transcription factors is involved in the positioning of the isthmus, which patterns the midbrain and cerebellum in vertebrates.

Gastrulation brain homeobox 2 (GBX2) methylation is associated with Gleason score (GS), pathologic stage (pT), and biochemical recurrence (BCR) in prostate cancer (PCa). Among intraductal carcinoma/cribriform architecture (IDC/C)-negative patients, GBX2 methylation improves prediction of BCR.

2020年4月1日 · Gbx1 and Gbx2, two members of the Gbx family of homeodomain-containing transcription factors, are known for their essential roles in central nervous system development. The expression domains of mouse Gbx1 and Gbx2 include regions of the forebrain, anterior hindbrain, and spinal cord.

Gbx2 misexpression in the anterior NPCs repressed the FM enhancer activity and inhibited Brn2 association with the enhancer, whereas Gbx2 knockdown caused ectopic Brn2 association in the posterior NPCs.

2025年2月8日 · homeobox protein GBX-2, gastrulation and brain-specific homeobox protein 2, stimulated by retinoic acid gene 7 protein. Gbx2 Identifies Two Amacrine Cell Subtypes with Distinct Molecular, Morphological, and Physiological Properties.