2024年12月25日 · GBP1 (Guanylate Binding Protein 1) is a Protein Coding gene. Diseases associated with GBP1 include Ulceroglandular Tularemia and Kaposi Sarcoma. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in …

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. [3][4] It belongs to the dynamin superfamily of large GTPases. [5] Guanylate binding protein expression is induced by interferon.

GBP1, the most widely studied GBP, has been studied for its antimicrobial properties. It can effectively polymerize and target the lipopolysaccharide cell wall of gram-negative bacteria.

2022年2月22日 · GBP1 identifies gram-negative bacteria such as the enteric pathogen, Salmonella enterica serovar Typhimurium, that enter the cytoplasm of the host cell. GBP1 then quickly connects to LPS and stimulates the assembly of more …

2019年7月1日 · GBP1 thus acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes. Our findings expand the immune roles of human GBPs in regulating not only pyroptosis, but also apoptosis.

2022年6月30日 · GBP1 is a 65-kD GTPase protein in the GBP family that plays a crucial role in innate immunity 14, comprising a conserved region with an N-terminal globular GTPase domain and a C-terminal...

2020年1月24日 · Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics.

2020年8月16日 · Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma. Yamakita I, et al. Biochem Biophys Res Commun, 2019 Oct 15. PMID 31421831. What's a GeneRIF? Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.

2022年7月29日 · Here, we show that guanylate-binding proteins (GBPs) mediate pathogen-selective inflammasome activation. We show that mouse GBP1 and GBP3 are specifically required for inflammasome activation...

2021年3月5日 · GBP1 represses the genomic transcription of VSV by competitively binding to the VSV-N substituting for the VSV-P, inhibits the nuclear delivery of KSHV virions by disrupting the actin filaments, and inactivating the viral particle of HEV by targeting the viral capsid protein to the lysosomal compartment.

Our results identify human GBP1 as the principal repetitive unit, numbering thousands of proteins per bacillus, that undergoes dramatic conformational opening to establish a host defense platform directly on the surface of gram-negative bacteria.

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression ...

2024年1月2日 · Guanylate binding protein 1 (GBP1) is the most concerned member of the GBP family, which has a series of effects such as anti-infection and anti-angiogenesis. Its role in malignant tumors including cervical cancer is still controversial. We aim to explore the effects of GBP1 on cervical cancer through bioinformatics and related experiments.

Interferon-gamma-induced GBP1 is an inhibitor of human papillomavirus 18. Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus. Function and mechanism of GBP1 in the development and progression of cervical cancer.

2022年2月18日 · Scientists recently made a significant breakthrough in the recognition of pathogens via guanylate binding protein 1 (GBP1). Wandel et al. [1] in Nature Immunology described their findings where GBP1 acts as a pattern recognition receptor that directly connects to lipopolysaccharide (LPS).

2024年6月24日 · Guanylate-binding protein 1 (GBP1) is one of the interferon-stimulating factors, which participates in the innate immunity of the host and plays an antiviral and antibacterial role. In this study, we explored how GBP1 is involved in IFN-α antiviral activity against HBV.

2024年10月15日 · Using cryo-electron microscopy (cryo-EM), cryo-electron tomography (cryo-ET) and biophysical assays, we show how GBP1 oligomers enwrap and remodel the lipopolysaccharide (LPS)-containing membrane...

2020年1月23日 · Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics.

2019年7月1日 · GBP 1 facilitated caspase‐4 recruitment to Salmonella leading to its enhanced activation and pyroptosis. Notably, GBP 1 could be bypassed by the delivery of Toxoplasma DNA or bacterial LPS into the cytosol, pointing to its role in liberating microbial molecules.

2023年11月17日 · Guanylate-binding protein 1 (GBP1) is known as an interferon-γ-induced GTPase. Here, we used genetically modified ovarian cancer (OC) cells to study the role of GBP1. The data generated show that GBP1 inhibition constrains the clonogenic potential of cancer cells.

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1 天前 · (Alliance News) - Hedge fund manager Crispin Odey has been fined GBP1.8 million and banned from the UK finance industry for a "lack of integrity", the financial watchdog has said in a provisional ...