GAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell.

2024年12月25日 · GAB2 (GRB2 Associated Binding Protein 2) is a Protein Coding gene. Diseases associated with GAB2 include Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 and Childhood Angiosarcoma. Among its related pathways are Insulin receptor signalling cascade and FLT3 signaling in disease.

Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, cytokines and antigen receptors.

蛋白包括Gab1、Gab2和Gab3。 该家族蛋白可通过介导膜受体与信号转导蛋白间的耦联及各信号分子间的相互作用参与信号 转导，其主要是通过激活SHP2/RAS/ERK和PI3K/AKT两条经典的信号通路，进而参与一系列的生物应答。

GAB2 is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer.

GAB2 is essential for two major signal transduction pathways in cancer, the PI3-K-AKT and extracellular signal-regulated kinase (ERK) signaling pathways, and thus regulates a number of key cellular processes.

2025年2月8日 · Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction. G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway. Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.

2021年4月8日 · Gab2 (Grb2-associated binder2) silencing suppresses thrombin-induced signaling and inflammation in endothelial cells. A, Human umbilical vein endothelial cells (HUVECs) were transfected with 200 nmol/L scrambled siRNA (scRNA), Gab1, or Gab2 siRNA. After 48 h, the cells were treated with thrombin (10 nmol/L) for 6 h.

Recent studies have highlighted that the Grb2-associated binder 2 (Gab2) is a critical gene involved in the development of various types of tumor, including CRC. However, the precise role of Gab2 in mediating TAM polarization remains incompletely elucidated.

Gab2 functions to mediate the activation of critical cell signaling pathways by multiple cell surface receptors for growth factors, cytokines, antigens, and immunoglobulins (Fig. 2).