2024年12月25日 · GRK2 (G Protein-Coupled Receptor Kinase 2) is a Protein Coding gene. Diseases associated with GRK2 include Short-Rib Thoracic Dysplasia 1 With Or Without …

G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. [5] GRK2 was initially called Beta-adrenergic receptor kinase (βARK or …

2023年8月2日 · Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gαq and the arrestin-biased ligand SBI-553 provide …

2025年2月8日 · GRK2-phosphorylated recombinant ribosomal protein P2 reconstitutes translational activity of 60S ribosomal subunits and represents a potential novel signaling …

2016年10月27日 · G-protein-coupled receptor kinase 2 (GRK2) is a G-protein-coupled receptor kinase that is ubiquitously expressed in many tissues and regulates various intracellular …

2012年3月1日 · In this review, we discuss traditional and newly discovered roles of GRK2 in receptor internalization and signaling as well as its impact on non-receptor substrates. We also …

2023年8月2日，中国科学院上海药物研究所徐华强研究员、段佳研究员和杨德华研究员共同在Nature杂志上发表了最新研究成果“GPCR activation and GRK2 assembly by a biased …

2009年12月28日 · G protein–coupled receptor kinase 2 (GRK2) plays a central role in G protein–coupled receptor regulation. Recent research is uncovering its involvement in …

2022年6月1日 · In addition to the inhibitory effect of GRK2/arrestins in GPCR signal transduction, emerging evidence suggests that GRK2 and β-arrestins regulate intracellular signaling …

2019年2月18日 · G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying …

2019年8月20日 · Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled …

In this review, we discuss traditional and newly discovered roles of GRK2 in receptor internalization and signaling as well as its impact on non-receptor substrates. We also discuss …

2024年7月3日 · G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed …

2017年1月1日 · GRK2 is a multidomain protein consisting of two regulator of G protein signaling (RGS) homology domains (RH; colored in red), a highly conserved serine/threonine kinase …

Down-regulation and desensitization of β-adrenergic receptors (β-AR) caused by G-protein-coupled receptor (GPCR) kinase 2 (GRK2) are prominent features of HF.

In this review, we discuss traditional and newly discovered roles of GRK2 in receptor internalization and signaling as well as its impact on non-receptor substrates. We also discuss …

该基因编码 G 蛋白偶联受体激酶蛋白家族的成员。 编码的蛋白质磷酸化 β-肾上腺素能受体以及广泛的其他底物，包括非 GPCR 细胞表面受体，以及细胞骨架、线粒体和转录因子蛋白。 来自 …

GRK2 is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRKs participate together …

2025年3月7日 · GRK2 with Paxil bound to its active site. Priyanka Naik, CC BY-ND. For example, in 2012, one of my colleagues discovered that the antidepressant Paxil could inhibit GRK2. To …

GRK2 is a RhoA effector that serves as a RhoA-activated scaffold protein for the ERK MAP kinase cascade. The ability of GRK2 to bind to Raf1, MEK1 and ERK2 is dependent on …