2024年12月25日 · GNAT3 (G Protein Subunit Alpha Transducin 3) is a Protein Coding gene. Diseases associated with GNAT3 include Invasive Malignant Thymoma and Dental Caries.Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and GABA B receptor activation.Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity.

242851 Ensembl ENSG00000214415 ENSMUSG00000028777 UniProt A8MTJ3 Q3V3I2 RefSeq (mRNA) NM_001102386 NM_001081143 RefSeq (protein) NP_001095856 NP_001074612 Location (UCSC) Chr 7: 80.46 – 80.51 Mb Chr 5: 18.17 – 18.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit ...

G 蛋白亚基α转导蛋白 3： 甜味、苦味和鲜味是通过特定的鸟嘌呤核苷酸结合蛋白从味觉受体传递而来的。该基因编码的蛋白质是这种异源三聚体 G 蛋白的 α 亚基，它不仅存在于口腔上皮细胞中，也存在于肠道组织中。该基因的变异与代谢综合征有关。[RefSeq 提供，2015 年 12 月]

2025年2月8日 · (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related traits. Several SNPs were associated with MS and its related traits. Remarkably. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY.

甜味、苦味和鲜味通过特定的鸟苷酸核苷酸结合蛋白从味道受体传递。这个基因编码的蛋白质是这种异源三聚G蛋白的α亚基，不仅存在于口腔上皮中，还存在于肠道组织中。这个基因的变异与代谢综合症有关。[RefSeq提供，2015年12月]

2025年1月13日 · Enables GTPase activity. Acts upstream of or within G protein-coupled receptor signaling pathway and sensory perception of taste. Located in cytoplasm. Part of heterotrimeric G-protein complex. Is expressed in alimentary system and liver. Orthologous to human GNAT3 (G protein subunit alpha transducin 3). [provided by Alliance of Genome Resources, Jan 2025]

2024年12月9日 · GNAT3 provided by HGNC Official Full Name G protein subunit alpha transducin 3 provided by HGNC Primary source HGNC:HGNC:22800 See related Ensembl:ENSG00000214415 MIM:139395; AllianceGenome:HGNC:22800 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage ...

Background & aims: Pancreatic ductal adenocarcinoma (PDA) initiation and progression are accompanied by an immunosuppressive inflammatory response. Here, we evaluated the immunomodulatory role of chemosensory signaling in metaplastic tuft cells (MTCs) by analyzing the role of GNAT3, a gustatory pathway G-protein expressed by MTCs, during PDA progression.

背景与目标 胰腺导管腺癌（PDA）的发生和进展伴随着免疫抑制炎症反应。在这里，我们通过分析 GNAT3（MTC 表达的味觉通路 G 蛋白）在 PDA 进展过程中的作用，评估了化学感应信号在化生簇细胞 (MTC) 中的免疫调节作用。 方法 Gnat3 -null ( Gnat3 -/- ) 小鼠与含有 Cre 诱导型Kras LSL-G12D/+等位基因的动物与Ptf1a ...

2024年8月14日 · GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in ...