Glutamic acid decarboxylase 67 (GAD67) is one of the isoforms that catalyze GABA synthesis. Subcutaneous inoculation of the GAD-expressing HSV vector transduces DRG neurons to produce GAD67 and release GABA, and the HSV vector reduces spinal cord injury-induced neuropathic pain (Liu et al., 2004).

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system, synthesized by two isoforms of glutamate decarboxylase (GAD): GAD65 and GAD67. GABA may act as a trophic factor during brain development, but its contribution to the development and maturation of cer …

We reveal a novel and specific role of GAD67-mediated GABA synthesis and signaling in regulating the maturation of inhibitory innervation pattern in the adolescent mouse visual cortex.

2014年12月17日 · Glutamate decarboxylase exists as two major isoforms, termed GAD65 and GAD67, that are usually expressed in GABA-containing neurons in the central nervous system. GAD65 has been proposed to be associated with GABA …

2020年5月26日 · Antibodies to glutamic acid decarboxylase (GAD) have been associated with several neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy. These antibodies...

2015年4月23日 · Decreased expression of the GABA synthetic enzyme glutamate decarboxylase 67 (GAD67) in a subset of GABAergic neurons, including parvalbumin (PV)-expressing neurons, has been observed in...

2002年12月1日 · The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD

2007年3月25日 · Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal 5′-phosphate–dependent enzyme glutamic acid decarboxylase (GAD65 and GAD67). GAD67 is constitutively active and...

Although GAD65 and GAD67 differ significantly in several characteristics, they also have substantial similarities and interactions, and the presence of individual forms of GAD in certain cell types is consistent with the idea that GAD65 and GAD67 …

GAD67, the larger isoform of theg-aminobutyric acid- synthesizing enzyme glutamic acid decarboxylase, is a hydrophilic soluble molecule, postulated to localize at nerve terminals and membrane compartments by het- erodimerization with …