2024年12月25日 · FOXA2 (Forkhead Box A2) is a Protein Coding gene. Diseases associated with FOXA2 include Combined Pituitary Hormone Deficiencies, Genetic Forms and …

2024年4月11日 · FOXA1 and FOXA2 have much crosstalk in steroid-hormone-associated cancers, for example, signaling pathways, epigenetic modifications, and post-translational …

2011年3月1日 · FOXA2 is a gene that plays a crucial role in the development and differentiation of dopamine neurons in the midbrain. It is expressed in the floor plate and is necessary for the …

2022年11月14日 · We identify that FOXA2 orchestrates prostate cancer adeno-to-neuroendocrine lineage transition and that Foxa2 expression is significantly induced by androgen deprivation. …

FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, …

2024年6月8日 · Overall, our findings underscore the pivotal role of FOXA2 as a pan-plasticity driver that rewires AP-1 to induce the differential transcriptional reprogramming necessary for …

Here we investigate the contribution of FOXA2 to coordinating intestinal epithelial cell function using postconfluent Caco2 cells, differentiated into an enterocyte-like model.

2004年12月23日 · Here we show that in normal mice, plasma insulin inhibits the forkhead transcription factor Foxa2 by nuclear exclusion and that in the fasted (low insulin) state Foxa2 …

FOXA2 was shown to regulate the expression of single genes within the intestine, including the apolipoprotein B locus, the gel-forming mucins, and the transcription factors Pax6 and HNF6 …

FOXA2 controls the anti-oxidant response in FH-deficient cells. FOXA2 suppresses PKM2 transcription and affects the Wnt/beta-catenin activity to block aerobic glycolysis in thyroid …

2024年4月11日 · This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies and highlights potential …

2025年2月8日 · Title: FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma. FOXA2 suppresses …

2024年4月11日 · FOXA1 and FOXA2 have much crosstalk in steroid-hormone-associated cancers, for example, signaling pathways, epigenetic modifications, and post-translational …

2025年3月12日 · Foxa2 f/f and Foxa2 f/f Ltf Cre/+ mice were housed in the animal care facility at Cincinnati Children’s Hospital Medical Center according to the National Institute of Health and …

2008年2月7日 · Foxa2 Regulates the Specification, Neurogenesis, and Differentiation of DA Neurons in the Midbrain Floor Plate. Dopaminergic neurons are born in the ventricular zone …

Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus and is a critical regulator of postnatal uterine gland differentiation in mice.

2022年8月16日 · Overexpression of FOXA2 reversed the defective phenotypes and improved hepatocyte functionality in iPSC-derived hepatic cells lacking FOXA2.

Foxa2 is a pioneer TF that can open compact chromatin and allows binding of cis-regulatory elements (CREs) for other TFs in a higher-order gene regulatory network (Burtscher et al., …

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. …

2010年6月9日 · Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We demonstrate here that inducible ablation of both transcription factors in …