2024年12月25日 · FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Alagille Syndrome 1. Among its related pathways are Signaling by ALK fusions and activated point mutants and Loss of proteins required for interphase microtubule organization from the centrosome.

2025年1月15日 · FOXM1 is transcriptionally super-active towards oncogenic targets in a phase-separated state, and we revealed a mechanism for the role of FOXM1 LLPS-mediated FKH-DNA binding. We identified...

FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis.

2021年6月19日 · As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell (CSC) properties, (5) genomic instability, and (6) altered cellular metabolism.

FOXM1 is a potent oncogenic factor essential for cancer initiation, progression and drug resistance. FOXM1 also drives the transcription of genes for DNA damage sensors, mediators, signal transducers and effectors. It plays an integral …

2023年7月14日 · FOXM1 overexpression facilitates mitotic exit and maintains chromosome segregation fidelity of MAD2-overexpressing and nocodazole-treated cells by disrupting SAC signaling.

2014年12月1日 · Forkhead Box M1 (FOXM1) is a bona fide oncofoetal transcription factor, which orchestrates complex temporal and spatial gene expression throughout embryonic and foetal development as well as during adult tissue homeostasis and repair.

FOXM1 is highly expressed in several cancers and has also been implicated in poor prognosis. A comprehensive understanding of various aspects of this molecule has revealed its role in angiogenesis, invasion, migration, self- renewal and drug resistance.

Oncogenic FOXM1 underwent liquid-liquid phase separation (LLPS) with FKH consensus DNA element, and compartmentalized the transcription apparatus in the nucleus, thereby sustaining chromatin accessibility and super-enhancer landscapes crucial for tumour metastatic outgrowth.

2023年6月27日 · We discuss new inhibitors of FOXM1 and highlight FOXM1 as an attractive target for controlling drug-resistant and difficult-to-suppress breast cancers, and how blocking FOXM1 might improve outcomes for patients with all subtypes of breast cancer.