2024年12月25日 · FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Pseudomyogenic Hemangioendothelioma and Osteoblastoma. Among its related pathways are IL-1 Family Signaling Pathways and ESR-mediated signaling.

In this review, we provide an overview of FOS and FOSB, including their functions and the differences between lesions with known FOS/FOSB gene rearrangements. Additionally, we discuss the use of FOS / FOSB immunohistochemistry as a diagnostic tool for these lesions.

2011年9月1日 · The fosB gene is an attractive candidate for regulating stress responses, because ΔFosB, an alternative splice product of the fosB gene, accumulates after repeated stress or antidepressant treatments.

The fosB gene produces two protein products through alternative splicing: full-length FosB (45 kDa) plus ΔFosB (∼35 kDa) that lacks the C terminal of the full-length form. By the use of antibodies directed against the N and C terminals of FosB, we found that the chronic FRAs are recognized by the N-terminal antibody only (data not shown).

2015年4月15日 · ΔFosB is a member of the Fos family of transcription factors. While other family members are induced rapidly but transiently in response to a host of acute stimuli, ΔFosB is unique in that it accumulates in response to repeated …

2005年11月1日 · The Fos family of transcription factors includes c-Fos (the human homolog of the retroviral oncogene v-Fos), FosB, Fra-1 and Fra-2 as well as smaller FosB splice variants FosB2 and deltaFosB2.

FOSB is a highly sensitive and diagnostically useful marker for pseudomyogenic hemangioendothelioma. our findings show that DeltaFosB increases the expression of MMP-9 and exhibits a significantly high survival and proliferation in MCF-7 cells.

2011年4月9日 · Transcription Factor FosB is a protein that is a member of the Fos family of transcription factors, which are regulated by neuronal activity and play a role in the transcriptional response to various stimuli in cells.

2022年4月16日 · ΔFosB is a member of the Fos family of transcription factors. While other family members are induced rapidly but transiently in response to a host of acute stimuli, ΔFosB is unique in that it accumulates in response to repeated …

FosB is a Mn 2+ -dependent fosfomycin-inactivating enzyme found in S. aureus that catalyzes nucleophilic addition of either l -cysteine (l -Cys) or bacillithiol (BSH) to the antibiotic, resulting in a modified compound with no bactericidal properties.

The transcription factor ΔFosB, a truncated splice isoform of FosB, accumulates in brain after several types of chronic stimulation. This accumulation is thought to be mediated by the unique stability of ΔFosB compared to all other Fos family proteins.

In this review, we describe and discuss the proposed role of ΔFosB as well as the implications of recent findings. The expression of ΔFosB displays variability dependent on the administered substance, showing region-specificity for different drug stimuli.

2022年1月12日 · Here, we summarize numerous insights from the past three decades of research into ΔFOSB structure, function, mechanisms of induction, and regulation of target genes that support its potential as a druggable target.

2011年9月1日 · Molecular mechanisms underlying stress tolerance and vulnerability are incompletely understood. The fosB gene is an attractive candidate for regulating stress responses, because ΔFosB, an alternative splice product of the fosB gene, accumulates after repeated stress or antidepressant treatments.

2020年8月24日 · We found that anlotinib treatment promotes TFEB nuclear translocation and enhances its transcriptional activity. When TFEB or ATP6V0E2 are knocked down, the enhanced lysosomal function and...

ΔFosB, a member of the Fos family of transcription factors, accumulates within a subset of neurons of the nucleus accumbens and dorsal striatum (brain regions important for addiction) after repeated administration of many kinds of drugs of abuse.

Fos 基因家族由 4 个成员组成：FOS、FOSB、FOSL1 和 FOSL2。 这些基因编码的亮氨酸拉链蛋白可以与 JUN 家族的蛋白二聚化，从而形成转录因子复合物 AP-1。 因此，FOS 蛋白被认为是细胞增殖、分化和转化的调节剂。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2.

2020年8月24日 · Meanwhile, FOS proteins FOSB and FOSL1 (FOS like 1) also mediate transcriptional responses to oxidative stress by dimerizing with proteins of the JUN family to form AP-1 (activator protein 1) complex 51,52.

2024年3月1日 · The results identified 13 regulons in males and 24 regulons in females, each representing a TF, along with a set of co-expressed and motif-enriched target genes. Among these, we noted several sex-specific TFs, including Egr1 and Irf7 in males and Cebpb, Etv1, Fosb, Klf13, Npdc1, Olig2, and Sox10 in females.

2025年2月5日 · There were 61 ARGs with risk rank I such as bla CTX-M, bla KPC-2, bla NDM-5/6, bla VIM-1/2, and fosB, and 7 ARGs with risk rank II, for example, bla CMY-2 and tet(O) (Supplementary Table 4). Several ARGs might encode resistance to the same antibiotic.