2024年12月25日 · FGFBP1 (Fibroblast Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with FGFBP1 include Colorectal Adenocarcinoma and Gallbladder Squamous Cell Carcinoma. Among its related pathways are Signaling by FGFR2 and Nuclear receptors meta-pathway.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. [ 5 ] [ 6 ] [ 7 ] FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner.

Gene ID: 9982, updated on 8-Feb-2025. This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their …

As a secreted protein, fibroblast growth factor-binding protein 1 (FGFBP1) binds and releases immobilized fibroblast growth factor (FGF) from the extracellular matrix. In addition, FGFBP1 enhances the activities of FGFs by chaperoning them to their receptors .

2025年2月8日 · Title: A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro.

Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in var …

FGFBP1 has been shown to play important roles at NMJs during development, normal aging and in ALS. It has also been found to be important for repairing neural circuits in the spinal cord. There is also evidence suggesting roles for both FGFBP1 and FGFBP3 in the formation and function of neural circuits in the brain.

2021年7月28日 · Fibroblast growth factor-binding protein 1 (FGFBP1) promotes fibroblast growth factor (FGF) activity by releasing FGFs from extracellular matrix storage.

2025年2月8日 · Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1). Fgfbp1 promotes blood-brain barrier development by regulating collagen IV …

2020年8月24日 · Fgfbp1 is expressed in the CNS endothelium and secreted into the vascular basement membrane during BBB formation. Endothelial genetic ablation of Fgfbp1 results in transient hypervascularization but delays BBB maturation in specific CNS regions, as evidenced by both upregulation of Plvap and increased tracer leakage across the neurovasculature ...