Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein that in humans is encoded (i.e., its formation is directed) by the FFAR4 gene. [5] . This gene is located on the long (i.e. "q") arm of chromosome 10 …

2024年12月25日 · FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include Body Mass Index Quantitative Trait Locus 10 and Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome. Among its related pathways are GPCR downstream signalling and Incretin synthesis, secretion, and inactivation.

FFAR4是一种G蛋白偶联受体（GPCR），主要在肠道上皮细胞、脂肪细胞、巨噬细胞等组织中表达。 它的作用机制是通过与长链脂肪酸，尤其是Omega-3多不饱和脂肪酸（ω-3 PUFA）结合，激活受体，进而通过Gαs蛋白激活腺苷酸环化酶（AC），导致cAMP水平增加，激活PKA和EPAC等下游信号通路，从而调节代谢和炎症反应。 FFAR4在生物学上的意义主要体现在其对代谢和免疫反应的调节作用。 作为Omega-3脂肪酸的传感器，FFAR4的激活可以促进胰高血糖素样肽 …

2021年8月1日 · Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120, is a long-chain fatty acid receptor highly expressed in adipocytes, endothelial cells, and macrophages. Activation of FFAR4 helps maintain metabolic homeostasis by regulating adipogenesis, insulin sensitivity, and inflammation.

2023年6月7日 · Omega (ω)-3 fatty acids are known to have multiple beneficial effects on health, including anti-inflammation, enhancement of glucose uptake and promotion of brain development. 1 The effects of ω-3...

2023年6月7日， 哈尔滨工业大学 何元政团队在 Cell Research （IF=46）在线发表题为“ Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity ”的研究论文， 该研究揭示了Omega-3脂肪酸受体FFAR4活化及G蛋白偶联选择性的结构基础。 考虑到FFAR4在维持代谢稳态中的重要性和治疗糖尿病的潜力，该研究解决了天然配体DHA结合的FFAR4与miniGs和miniGsq复合物，合成激动剂gw9508结合的FFAR4与miniGsq复合物的冷 …

2025年2月8日 · GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease. Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus. Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.

Free fatty acid receptors (FFARs) are a class of G protein-coupled receptors (GPCRs) that have wide-ranging effects on human physiology. The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. Short-chain (<6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41.

2025年1月13日 · Here we show that the expression of free fatty acid receptor Ffar4, a receptor for long-chain fatty acids, is decreased in patients and mouse models with diabetes, which is...

该基因编码属于 GPR 视紫红质家族的 G 蛋白偶联受体 (GPR) 。 编码的蛋白质充当游离脂肪酸 (包括 omega-3) 的受体，并参与抑制抗炎反应和胰岛素敏化。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2012 年 2 月] This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs.