2024年12月25日 · FBXO32 (F-Box Protein 32) is a Protein Coding gene. Diseases associated with FBXO32 include Left Ventricular Noncompaction and Dilated Cardiomyopathy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Gene expression (Transcription). An important paralog of this gene is FBXO25.

FBXO32 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [9] For this reason, FBXO32 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

2025年2月8日 · FBXO32 activates NF-kappaB through IkappaBalpha degradation in inflammatory and genotoxic stress; Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 and its transcription factor FOXO3A.

F-box 蛋白 32： 该基因编码 F-box 蛋白家族的一个成员，其特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和 ...

2017年11月15日 · Fbxo32 showed strong transcriptional induction during TGF-β-induced EMT in NMuMG cells (Fig 1b, d, Supplementary Fig. 2a).FBXO25, the closest evolutionarily conserved member to FBXO32 (based on ...

2025年2月8日 · Title: The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression. Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp …

F-框蛋白 32 （FBXO32），也被称为 MAFbx ，表示“ 肌肉萎缩 F-box 基因 ”， 是由 FBXO32 基因编码的蛋白质。 该基因编码 F-box 蛋白家族的成员，其特 征 在 于 大 约 40 个 氨 基 酸 基 序 F-box 。 F-box 蛋 白 构 成 称 为 SCF (SKP1-cullin-F-box)的 泛素蛋白连接酶复合物 的四个亚基之一，其在磷酸化 中起作用依赖性 ...

2024年8月27日 · 近期研究揭示了FBXO32在肿瘤发生中的多重作用。重要的是，FBXO32通过为乳腺癌中的上皮–间质转化进程创建适宜环境来促进转移。然而，FBXO32在PDAC进展中的病理功能和机制仍未明了。 模式机理图（图片源自Cancer Research）

2015年6月26日 · FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood. Here, we present evidence that FBXO3 …

2024年4月20日 · FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by ...