FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis.

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FAS-associated protein with death domain (FADD) is the key adaptor protein transmitting apoptotic signals mediated by the main death receptors (DRs). Besides being an essential instrument in cell death, FADD is also implicated in proliferation, cell cycle progression, tumor development, inflammation …

2022年11月8日 · Fas-associated protein with death domain (FADD) was initially identified as an adaptor protein for death receptor-mediated extrinsic apoptosis. Recent evidence suggests that FADD plays a vital role in non-apoptotic cellular processes, …

2024年12月25日 · FADD (Fas Associated Via Death Domain) is a Protein Coding gene. Diseases associated with FADD include Immunodeficiency 90 With Encephalopathy, Functional Hyposplenia, And Hepatic Dysfunction and Fadd-Related Immunodeficiency. Among its related pathways are TNFR1 Pathway and Regulation by c-FLIP.

FADD was initially described as an adaptor molecule for death receptor-mediated apoptosis, but subsequently it has been implicated in nonapoptotic cellular processes such as proliferation and cell cycle control. During the last decade, FADD has been ...

2024年3月12日 · Fas-associated death domain (FADD) is an adaptor protein that predominantly transduces the apoptosis signal from the death receptor (DR) to activate caspases, leading to the initiation of apoptotic signaling and the coordinated removal of …

Our findings highlight the key role of FADD in Fas-dependent and Fas–independent signaling pathways in humans. Germline mutations in FASL1 (MIM 134638) and FAS2,3 (MIM 134637) are genetic etiologies of autoimmune lymphoproliferative syndrome (ALPS [MIM 601859]) in humans.

The data identify FADD as a novel component of the noncanonical TLR4/IFN-beta signaling pathway and demonstrate that both Fas and its adaptor FADD can differentially regulate the production of LPS-induced proinflammatory cytokines and type I interferons.

2012年7月31日 · Fas-associated protein with death domain (FADD) is a pivotal component of death receptor-mediated extrinsic apoptosis and necroptosis. Here we show that FADD is regulated by Makorin...