FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations.

2021年11月18日 · FK506-binding proteins (FKBPs) belong to the immunophilin family. Like other immunophilins many FKBPs possess a cis-trans peptidyl-prolyl isomerase (PPIase) activity. In addition, they can act as a co-receptor for the natural products FK506 and Rapamycin.

FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands. The roles of immunophilins in protein transportation and apoptosis through their molecular interactions with receptors or proteins have emerged recently.

Since FK506-binding proteins (FKBP) were first identified, much progress has been made in understanding the mechanisms involved in regulating the immunological process, steroid signaling, and the resulting roles they play in physiological processes.

2018年12月5日 · High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments.

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its members have fundamental roles in the regulation of signalling pathways involved in inflammation, adaptive immune responses, cancer and developmental biology.

2024年12月25日 · FKBP4 (FKBP Prolyl Isomerase 4) is a Protein Coding gene. Diseases associated with FKBP4 include Hypospadias and Ocular Hypertension. Among its related pathways are Infectious disease and ESR-mediated signaling. Gene Ontology (GO) annotations related to this gene include RNA binding and protein-macromolecule adaptor activity.

2018年1月1日 · FKBP (FK506 Binding Protein), Table 1 FKBP classification with synonyms of gene and protein. In the 1970s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis.

FKBP52为FK506结合蛋白...

2011年8月1日 · FKBPs participate in cancer cellular processes. FKBPs are implicated in cell growth and survival and apoptotic signaling pathways. FKBP51 provide a relevant tissue marker of chemo-sensitivities and radio-sensitivities. FKBP52 autoantibodies are promising diagnostic cancer biomarkers.

2024年12月25日 · FKBP10 (FKBP Prolyl Isomerase 10) is a Protein Coding gene. Diseases associated with FKBP10 include Bruck Syndrome 1 and Osteogenesis Imperfecta, Type Xi. Among its related pathways is Type I collagen synthesis in …

2015年11月2日 · FK506 binds to a different immunophilin than CsA, called FK506-binding protein (FKBP) 12 13. Differences between CsA and FK506 with regard to adverse effects, safety and tolerability have been observed 14 - 19. Targeting calcineurin, CsA can control allograft T cell immunity through myeloid-derived suppressive cells 20, 21.

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations.

In this study, we identified a subpopulation of CD146 + TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling.

Methods: Unilateral ischemia/reperfusion-induced AKI to CKD mouse model and TGF-β-treated pericyte-like cells were used to detect the levels of fatty acid oxidation (FAO) and glycolysis, and the critical signaling pathways during PMT under the …

2018年12月5日 · FK506-binding proteins (FKBPs) belong to the immunophilin family. Like other immunophilins many FKBPs possess a cis-trans peptidyl-prolyl isomerase (PPIase) activity. In addition, they can act as a co-receptor for the natural products FK506 and Rapamycin.

In this article, a variety of SIS3 derivatives were designed and synthesized to discover potential inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of a 2- (4- (pyridin-2-yl)phenoxy)pyridine analogue.

FK506-binding proteins (FKBPs) belong to the immunophilin family and bind immunosuppressive drugs, such as FK506 and rapamycin.

Here, this work develops a strategy using novel trimethylamine N-oxide (TMAO)-derived zwitterionic hydrogel to promote diabetic wound healing, and explore the multi-cellular ecosystem around zwitterionic hydrogel, mapping out an overview of different cells in the zwitterionic microenvironment by single-cell RNA Sequencing.

Results: In this study, we showed that E3 Ligase Smurf1 enhanced Nrf2 activation and promoted Autophagy by increasing p62 phase separation capability. Specifically, the Smurf1/ p62 interaction improved the formation and material exchange of liquid droplets compared with p62 single puncta.