2024年7月31日 · Nature - FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the...

2024年12月25日 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group D2 and Fanconi Anemia, Complementation Group A. Among its related pathways are Gene expression (Transcription) and miRNA regulation of DNA damage response.

Available data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway and more specifically FANCD2 and its interacting proteins in pathways of genomic surveillance and maintenance will be discussed in this chapter.

2017年8月19日 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage.

2021年1月29日 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.

2024年1月23日 · We propose a model wherein SRSF1 and FANCD2 interaction links DNA damage response to the avoidance of pathogenic R-loops via regulation of mRNA export.

FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions. Pancancer analysis of the prognostic and immunological role of FANCD2: a potential target for carcinogenesis and survival. FANCD2 deficiency sensitizes SHH …

2020年2月17日 · FANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). Ubiquitin is positioned at the interface of...

2017年8月19日 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.

2014年5月22日 · We propose that FANCD2 is essential for efficient end resection during ICL repair by promoting CtIP localization in chromatin. To gain insight into FANCD2 function, we sought to identify proteins associated with FANCD2 in response to replication stress.