
Prostaglandin EP4 receptor - Wikipedia
EP4 4 receptors are expressed in the cochlea of the inner ear. Pre- and post-treatment of guinea pigs with an EP4 agonist significantly attenuated threshold shifts of auditory brain stem …
E-type prostanoid receptor 4 (EP4) in disease and therapy
In this review, we summarize the physiological roles of EP4, its molecular structure and intracellular signaling pathways, and how EP4 receptors might be targeted pharmacologically …
Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac …
Prostaglandin E 2 (PGE 2) receptor EP4 is essential for cardiovascular homeostasis. This study aims to investigate the roles of cardiomyocyte (CM) and cardiac fibroblast (CF) EP4 in …
E-type prostanoid receptor 4 (EP4) in disease and therapy
In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been …
EP4: A prostanoid receptor that modulates insulin signalling in rat ...
The EP4 (prostaglandin E2) receptor plays a crucial role in myogenesis and skeletal muscle regeneration, yet its involvement in regulating insulin-dependent metabolic pathways is not …
EP4 Receptor - an overview | ScienceDirect Topics
An EP4 receptor is a type of cell surface receptor that, upon binding with PGE2, regulates cell signaling pathways, including cAMP/PKA-dependent pathways as well as other pathways like …
Ligand binding to human prostaglandin E receptor EP4 at the …
2018年12月3日 · Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal structure of …
A novel prostaglandin E receptor 4 (EP4) small molecule …
2022年3月8日 · We developed a novel EP4 antagonist HL-43 that can promote cartilage repair, enhance stable mature articular cartilage formation instead of fibrocartilage formation, delay …
Prostaglandin E Receptor EP4 expression, survival and pattern of ...
EP4 overexpression has a number of potential effects that may enhance the development and spread of malignancy. PGE2 induces migration of tumor cells in vitro and endogenous EP4 …
Prostaglandin E2 receptor EP4 as the common target on cancer …
2014年9月11日 · As long-term use of COX-2 inhibitors (COX-2i) can promote thrombo-embolic events, we tested an alternative target, prostaglandin E2 receptor EP4 subtype (EP4), …
- 某些结果已被删除