EP4 4 receptors are expressed in the cochlea of the inner ear. Pre- and post-treatment of guinea pigs with an EP4 agonist significantly attenuated threshold shifts of auditory brain stem responses and significantly reduced the loss of outer hair cells caused by prior noise exposure.

In this review, we summarize the physiological roles of EP4, its molecular structure and intracellular signaling pathways, and how EP4 receptors might be targeted pharmacologically for the benefit of human disease, including vascular and …

Prostaglandin E 2 (PGE 2) receptor EP4 is essential for cardiovascular homeostasis. This study aims to investigate the roles of cardiomyocyte (CM) and cardiac fibroblast (CF) EP4 in isoproterenol (ISO)-induced cardiac fibrosis.

In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been proposed for the EP4 receptor, along with its recently described unfavorable tumor-promoting and pro-angiogenic roles.

The EP4 (prostaglandin E2) receptor plays a crucial role in myogenesis and skeletal muscle regeneration, yet its involvement in regulating insulin-dependent metabolic pathways is not well characterised.

An EP4 receptor is a type of cell surface receptor that, upon binding with PGE2, regulates cell signaling pathways, including cAMP/PKA-dependent pathways as well as other pathways like PI3K/AKT/mTOR and MAPK pathways.

2018年12月3日 · Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal structure of human EP4 in complex with...

2022年3月8日 · We developed a novel EP4 antagonist HL-43 that can promote cartilage repair, enhance stable mature articular cartilage formation instead of fibrocartilage formation, delay chondrocyte terminal...

EP4 overexpression has a number of potential effects that may enhance the development and spread of malignancy. PGE2 induces migration of tumor cells in vitro and endogenous EP4 signaling promotes metastasis in vivo. EP4 is highly expressed on human and mouse breast cancer cell lines.

2014年9月11日 · As long-term use of COX-2 inhibitors (COX-2i) can promote thrombo-embolic events, we tested an alternative target, prostaglandin E2 receptor EP4 subtype (EP4), downstream of COX-2.