EP4 4 receptors are expressed in the cochlea of the inner ear. Pre- and post-treatment of guinea pigs with an EP4 agonist significantly attenuated threshold shifts of auditory brain stem …

In this review, we summarize the physiological roles of EP4, its molecular structure and intracellular signaling pathways, and how EP4 receptors might be targeted pharmacologically …

Prostaglandin E 2 (PGE 2) receptor EP4 is essential for cardiovascular homeostasis. This study aims to investigate the roles of cardiomyocyte (CM) and cardiac fibroblast (CF) EP4 in …

In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been …

The EP4 (prostaglandin E2) receptor plays a crucial role in myogenesis and skeletal muscle regeneration, yet its involvement in regulating insulin-dependent metabolic pathways is not …

An EP4 receptor is a type of cell surface receptor that, upon binding with PGE2, regulates cell signaling pathways, including cAMP/PKA-dependent pathways as well as other pathways like …

2018年12月3日 · Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal structure of …

2022年3月8日 · We developed a novel EP4 antagonist HL-43 that can promote cartilage repair, enhance stable mature articular cartilage formation instead of fibrocartilage formation, delay …

EP4 overexpression has a number of potential effects that may enhance the development and spread of malignancy. PGE2 induces migration of tumor cells in vitro and endogenous EP4 …

2014年9月11日 · As long-term use of COX-2 inhibitors (COX-2i) can promote thrombo-embolic events, we tested an alternative target, prostaglandin E2 receptor EP4 subtype (EP4), …