EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

2024年12月24日 · EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Myelodysplastic Syndrome and Ischemia. Among its related pathways are PIP3 activates AKT signaling and Hepatocyte growth factor receptor signaling.

2021年11月10日 · Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of cardiovascular and inflammatory disorders.

2023年11月17日 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif.

Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coli. Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1.

2019年8月29日 · With unbiased data-driven approaches, we predicted that Egr1, a transcription factor important for memory formation, plays an essential role in brain epigenetic programming. We performed EGR1...

Egr-1(early growth responsive gene-1,Egr-1)是重要的核转录因子,其编码多种蛋白,在调控细胞的生长,分化,发育,增殖,炎性反应等方面发挥重要作用,本文针对其基因结构及特点,生物学特性,与肿瘤,炎症及肝损伤的关系作一简要综述.Egr-1基因及其蛋白的结构与特点Egr-1基因编码 ...

研究者使用Egr-1基因敲除小鼠（Egr-1−/−）来评估Egr-1对VEGFA、PDGFB和ANGPTL4生产的影响。 通过酶联免疫吸附试验（ELISA），研究者发现感染导致的VEGFA、PDGFB和ANGPTL4在 Egr-1−/− 小鼠脑中的上调明显低于野生型（WT）小鼠（Fig 7A）。

该基因编码的蛋白属于 C2H2 型锌指蛋白 EGR 家族。 它是一种核蛋白，起着转录调节剂的作用。 它激活的靶基因的产物是分化和有丝分裂发生所必需的。 研究表明这是一种癌症抑制基因。 [RefSeq 提供，2014 年 12 月] The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator.

2024年8月11日 · 通过在巨噬细胞中过表达EGR1，研究者发现它能够减轻LPS刺激引起的炎症增强子活性，进而减弱炎症反应，表现为细胞因子（如TNFα、IL-12和IL-6）水平的降低，并改变免疫表型，显示出EGR1在调节巨噬细胞炎症反应中发挥的抗炎作用。