2024年12月24日 · EGLN2 (Egl-9 Family Hypoxia Inducible Factor 2) is a Protein Coding gene. Diseases associated with EGLN2 include Pheochromocytoma and Polycythemia. Among its related pathways are Cellular responses to stimuli and …

ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins. The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation.

2025年2月8日 · The identification of EGLN2 as a significantly deregulated gene that maps within the paired chromosome region directly implicates defects in the oxygen-sensing network to the biology of renal oncocytoma.

缺氧诱导因子 (HIF) 是一种参与氧稳态的转录复合物。 在正常氧气水平下， HIF 的 α 亚基被脯氨酰羟基化作用靶向降解。 该基因编码负责这种翻译后修饰的酶。 可变剪接导致多个转录本变体。 该基因与上游 RAB4B (RAB4B，成员 Ras 致癌基因家族) 基因之间也存在通读转录。 [RefSeq 提供，2011 年 2 月] The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis.

这些数据表明通过激活HIF羟化酶抑制缺氧诱导的HIF-1α激活可以提供一种抑制肿瘤生长和新生血管形成的新治疗策略，并支持基于激活HIF脯氨酰羟化酶的基因转移方法的发展。 缺氧应激是实体瘤微环境中的主要选择性压力之一，克服这一限制对于肿瘤的进展至关重要。 引起细胞对缺氧反应的关键因素之一是缺氧诱导因子（HIF），这是一种关键的转录因子。 HIF-1的α亚基的水平受到脯氨酰羟化酶（PHDs / EGLNs）家族控制的快速降解的调节，其活性取决于氧气的供应。 我们 …

2024年9月9日 · Germeys et al. identify EGLN2 as an ALS target that, when downregulated, protects motor neurons and mitigates the ALS phenotype in ALS zebrafish and mice. Using snRNA-seq and CRISPR-Cas9-edited patient iPSCs, they show that the downregulation of EGLN2 normalizes the STING-induced astrocytic interferon response in vivo and in …

EGLN2 encodes the oxygen-sensing enzyme prolyl hydrolase 1 (PHD1) responsible for mediating the HIF-1α degradation and related to tumor progression. EGLN2 is implicated as a tumor suppressor, since its overexpression could inhibit the tumor growth in colon cancer cell .

2025年2月8日 · Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury. PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.

egln1、egln2和egln3是脯氨酸羟化酶，其主要功能是调节hif因子。它们作为氧传感器工作，是常氧环境中 hifα 亚基降解的主要负责人。由于它们的活动严格依赖于氧，当氧张力降低时，它们对 hifα 的控制就会被释放，从而激活全身和细胞对缺氧的反应。

2017年1月24日 · EglN2 contributes to ERα-positive breast tumorigenesis by acting as an estrogen-inducible gene. However, the detailed molecular mechanism(s) underlying the post-transcriptional regulation of EglN2 and its potential role in Triple Negative Breast Cancer (TNBC) remains largely unclear.