2024年12月25日 · ETV1 (ETS Variant Transcription Factor 1) is a Protein Coding gene. Diseases associated with ETV1 include Skeletal Ewing Sarcoma and Soft Tissue Sarcoma. Among its related pathways are Akt Signaling and MAPK-Erk Pathway.

2010年10月3日 · We propose that GIST arises from ICCs with high levels of endogenous ETV1 expression that, when coupled with an activating KIT mutation, drives an oncogenic ETS transcriptional program.

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene. [5] [6]

2019年6月3日 · First, we discovered that ETV1 forms complexes with SMAD4. Second, SMAD2, SMAD3 and SMAD4 overexpression impaired ETV1’s ability to stimulate gene transcription.

2018年7月2日 · Cardiomyocyte-specific deletion of ETV1 results in cardiac conduction abnormalities, decreased expression of rapid conduction genes (Nkx2–5, Gja5, and Scn5a), HPS hypoplasia, and...

ETV1 and COP1 are a pair of independent predictors of prognosis for triple-negative breast cancer. ETV1 overexpression is associated with prostate cancer aggressiveness. Results show that ETV1 was upregulated at a higher rate in Gastrointestinal stromal tumor and was correlated with KIT expression.

2016年10月24日 · ETV1 is a NRG1-responsive factor that is highly expressed in PAM and VCS myocytes, where it establishes the fast conduction phenotype through enrichment of Nkx2-5, Gja5, and Scn5a. Consequently, Etv1 -deficient mice exhibit cardiac conduction defects and developmental abnormalities of the VCS.

2015年12月8日 · ETV1, which is mutated in prostate cancer more often, was degraded after being ubiquitinated by COP1. Truncated ETV1 encoded by prostate cancer translocation TMPRSS2:ETV1 lacks the critical COP1 binding motifs and …

Here, we review evidence for a role of ETV1, 4 and 5 as oncoproteins and describe modes of their action. Modulation of their activation or interaction with cofactors as well as inhibiting crucial target gene products may ultimately be exploited to treat various cancers that are dependent on the PEA3 group of ETS transcription factors.

2024年11月2日 · Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression.