2023年11月23日 · 癌症治疗领域： enpp1抑制剂 是一种针对癌症免疫治疗的新型药物，它的作用机制是通过阻断enpp1的活性，从而增强肿瘤细胞外的cgamp信号，激活邻近的免疫细胞，同时减少免疫抑制性的腺苷分子，从而促进抗肿瘤免疫反应。

2024年12月24日 · ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) is a Protein Coding gene. Diseases associated with ENPP1 include Cole Disease and Hypophosphatemic Rickets, Autosomal Recessive, 2. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Endochondral ossification with skeletal dysplasias.

ENPP1 has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars. ENPP1 protein may function to hydrolyze nucleoside 5′-triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates.

ENPP1, as a highly potent cGAMP-degradation enzyme, makes the application of ENPP1 inhibitors for anti-tumor therapy a very topical issue. For virally-infected hosts, small molecule inhibitors of ENPP1 would also need to inhibit viral poxins for maximum efficacy.

enpp1抑制可增强对肿瘤免疫检查点抑制疗法的应答. 研究人员还对人类癌症样本中的enpp1进行了研究，他们发现enpp1的表达与转移增加和对 免疫疗法 的耐药有关。 enpp1的表达与人类癌症的转移有关. enpp1位于癌细胞表面，这使得阻断药物的靶向难度降低。

2023年9月22日 · enpp1是胞外环磷酸鸟苷-腺苷合成酶（cgamp）最主要的水解酶，可以将其水解为amp和gmp，从而提高胞外腺苷水平。 研究表明，腺苷水平过高会抑制免疫细胞的功能，而肿瘤中的腺苷水平常常远高于正常组织。

2019年11月19日 · This emerging role of ENPP1 has placed this "old" enzyme at the frontier of immunotherapy. This review highlights the roles played by ENPP1, the mechanism of cGAMP hydrolysis by ENPP1, and small molecule inhibitors of ENPP1 with potential applications in diverse disease states, including cancer.

ENPP1 is a genetic determinant of obesity-related phenotypes in a Mexican American population with type 2 diabetes mellitus. The prevalence of the PC-1 121Q allele was significantly higher in type 2 diabetic patients who suffered from CHD, compared to type 2 …

The ENPP1 gene provides instructions for making a protein called ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). The ENPP1 protein helps break down a molecule called adenosine triphosphate (ATP), specifically when it …

Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7) have been implicated in key biological and pathophysiological processes, including nucleotide and phospholipid signaling, bone mineralization, fibrotic diseases, and ...