Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. [5][6] The protein encoded by this gene is a member of the E2F family of transcription factors.

2024年12月24日 · E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include Colorectal Cancer and Retinoblastoma. Among its related pathways are Aberrant regulation of mitotic G1/S transition in …

2019年7月3日 · Here we show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells. In these cells, E2F4 acts in part as a transcriptional activator that promotes the...

The E2F family of transcription factors is a key determinant of cell proliferation in response to extra- and intra-cellular signals. Within this family, E2F4 is a transcriptional repressor whose activity is critical to engage and maintain cell cycle ...

E2F4, binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells; By interacting with p130, E2F4 plays a key role in the maintenance of a stable G2 arrest. Increased E2F4 levels and its translocation to the nucleus following genotoxic stress result in downregulation of mitotic genes.

该基因编码的蛋白质是 E2F 转录因子家族的成员。 E2F 家族在控制细胞周期和肿瘤抑制蛋白的作用中起着至关重要的作用，也是小 DNA 肿瘤病毒转化蛋白的靶标。 E2F 蛋白包含几个在大多数家族成员中发现的进化保守结构域。 这些结构域包括 DNA 结合结构域、决定与分化调节转录因子蛋白 (DP) 相互作用的二聚化结构域、富含酸性氨基酸的反式激活结构域，以及嵌入反式激活结构域内的肿瘤抑制蛋白关联结构域。 该蛋白与所有三种肿瘤抑制蛋白 pRB、p107 和 p130 结合， …

过去普遍认为E2F4是肿瘤抑制因子，但近年来研究表明，E2F4可促进多种肿瘤的发生、发展和转移。 本文主要对E2F4的结构、功能和在不同肿瘤中的作用及其机制进行综述，以探讨E2F4在肿瘤细胞生命活动中的意义，为肿瘤诊治和预后判断中靶点的选择提供参考。 中图分类号: 杨莉, 苟巧. E2F转录因子4在肿瘤中的研究进展 [J]. 癌变·畸变·突变, 2024, 36 (6): 506-509. 导出引用管理器 EndNote | Reference Manager | ProCite | BibTeX | RefWorks. 链接本文: …

The E2F family of transcription factors has important roles in cell cycle progression. E2F4 is an E2F family member that has been proposed to be primarily a repressor of transcription, but the scope of its binding activity and functions in ...

E2F4 binds p130 and localizes to the nucleus following PC12 cell differentiation. E2F4 interactions with Rb family proteins have a major impact on E2F4 function, including its conversion from a trans-activator into a repressor of E2F-regulated cell cycle genes (22, 39).

E2F4 is a member of the E2F family of transcription factors that associates with Rb, p107, and p130, primarily involved in the active repression of E2F-responsive genes. AI generated definition based on: Handbook of Immunohistochemistry and in …