2024年12月24日 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma. Among its …

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F …

E2F1 shows structural homology with other E2F activators. It has a single DNA binding domain and heterodimerizes with a dimerization partner (DP1/DP2) in order to effectively bind DNA …

Using a conditional gene-targeting approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibroblasts …

2019年5月3日 · This study shows that minor copy number changes (one to two extra copies) of E2f1 or E2f3b are sufficient to induce liver cancer in mice.

2017年11月10日 · We summarize recent findings about the cell cycle-independent roles of E2F1 in various tissues that contribute to global metabolic homeostasis and highlight that E2F1 …

E2F1 has a cancer protective role in oncogenic BRAF-activated melanoma cells. E2F1 promotes the transcription of lncRNA RGMB-AS1 in papillary thyroid carcinoma (PTC). blocking E2F1 …

2025年2月11日 · E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling. E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating …

2023年12月3日 · E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway. Song L, Li H, Ma RR, Liu S, …

2014年12月5日 · E2F1 and FOXO3 are two transcription factors that have been shown to participate in cellular senescence. Previous report reveals that E2F1 enhanced cellular …