2024年12月24日 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma. Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Mitotic G1 phase and G1/S transition.

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required.

E2F1 shows structural homology with other E2F activators. It has a single DNA binding domain and heterodimerizes with a dimerization partner (DP1/DP2) in order to effectively bind DNA and recruit other transcription factors and co-activators to target gene promoters.

Using a conditional gene-targeting approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibroblasts leads to the activation of p53 and the induction of p53 target genes, including p21CIP1.

2019年5月3日 · This study shows that minor copy number changes (one to two extra copies) of E2f1 or E2f3b are sufficient to induce liver cancer in mice.

2017年11月10日 · We summarize recent findings about the cell cycle-independent roles of E2F1 in various tissues that contribute to global metabolic homeostasis and highlight that E2F1 activity is increased during obesity.

E2F1 has a cancer protective role in oncogenic BRAF-activated melanoma cells. E2F1 promotes the transcription of lncRNA RGMB-AS1 in papillary thyroid carcinoma (PTC). blocking E2F1 also induced death of melanoma cells resistant to BRAF inhibitors.

2025年2月11日 · E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling. E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT. Context-Dependent Functions of E2F1: Cell Cycle, Cell Death, and DNA Damage Repair in Cortical Neurons.

2023年12月3日 · E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway. Song L, Li H, Ma RR, Liu S, Zhang GH, Guo XY, Zhao RN, Wu XJ, Zhang K, Gao PSong L, et al .

2014年12月5日 · E2F1 and FOXO3 are two transcription factors that have been shown to participate in cellular senescence. Previous report reveals that E2F1 enhanced cellular senescence in human fibroblast cells, while FOXO transcription factors play against senescence by regulation reactive oxygen species scavenging proteins.