Dicer - Wikipedia
Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves …
DICER: structure, function, and regulation - PMC - PubMed …
DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes. DICER is encoded by a single gene in vertebrates and C. elegans, …
Molecular mechanisms of Dicer: endonuclease and enzymatic …
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small …
Structure of the human DICER–pre-miRNA complex in a dicing state
2023年2月22日 · Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity …
DICER1 Tumor Predisposition - GeneReviews® - NCBI Bookshelf
2014年4月24日 · DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular …
DICER: structure, function, and regulation - PubMed
2021年11月16日 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms …
What is the DICER1 gene? - Cancer
What is the DICER1 gene? Everyone inherits two copies of the DICER1 gene from their parents, one from their mother and one from their father. This gene works to manage the function of …
Sequence determinant of small RNA production by DICER
2023年2月22日 · Dicer, a multidomain ribonuclease (RNase) III, serves as a key player in RNA silencing by cleaving double-stranded RNA (dsRNA) into small RNAs of 21–25 nucleotides (nt) …
DICER: structure, function, and regulation | Biophysical Reviews
2021年11月16日 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms …
Determinants of selectivity in the dicing mechanism
2024年10月18日 · DICER is a vital enzyme in small RNA production. Here the authors show how bipartite pairing rules and dual YCR motifs guide DICER's activity on precursor microRNAs.