2024年12月24日 · DHX9 (DExH-Box Helicase 9) is a Protein Coding gene. Diseases associated with DHX9 include Intellectual Developmental Disorder, Autosomal Dominant 75 and Werner Syndrome. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Cytosolic sensors of pathogen-associated DNA.

2024年1月29日 · 近日，美国费城肿瘤医院 Israel Canadas 团队在 Cancer Discovery 期刊上发表题为 Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer 的研究论文， 通过基于CRISPR的RNA解旋酶筛选，确定DExD/H-box解旋酶9 （DHX9） 是SCLC中双链RNA （dsRNA） 的 ...

2017年4月6日 · dhx9通过与adar(p150)相互作用，促进这种双链rna结构的解螺旋，微调控基因转录产物的剪接作用和转录后产物的功能。dhx9基因敲除后会大大提高环状rna形成的数目和种类。 图16 dhx9调控rna剪接和功能 （来自[1]） 本文的工作非常细致全面，实验设计也非常严谨。

ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene. [5] [6] [7]

2024年4月9日 · Through Dhx9 ΔIEC, Dhx9 ΔPaneth, and Dhx9 iΔISC mice and organoids, we demonstrated that DHX9 is crucial for maintaining intestinal homeostasis. Mechanistically, the loss of DHX9 leads to...

2023年2月3日 · In this study, we generated myeloid-specific and hepatocyte-specific DHX9 knockout mice (Dhx9 f/f LysM-Cre and Dhx9 f/f Alb-Cre) and tested the in vivo role of DHX9 in anti-RNA virus immune responses in macrophages and hepatocytes.

2024年3月18日 · Daughter cells arising from UV-exposed mother cells assemble stress granules that are marked by the dsRNA helicase DHX9. These stress granules sequester damaged intron RNA and activate several stress responses as a protective mechanism.

2021年7月5日 · We show that DHX9 plays a critical role in HR by promoting the recruitment of BRCA1 to RNA as part of the RNA Polymerase II transcription complex, where it facilitates the resection of DSB.

2023年2月9日 · dhx9是一种多功能核蛋白，目前尚不清楚它是否在调节细胞核中针对rna病毒的先天免疫中发挥作用。 这项研究表明，DHX9与体内针对RNA病毒感染的先天免疫应答密切相关。

2023年8月3日 · DHX9 encodes a BRCA1-interacting nuclear helicase regulating transcription, R-loops, and homologous recombination and exhibits the highest mutational constraint of all DDX/DHX paralogs but remains unassociated with disease traits in OMIM.