2024年12月24日 · DDX21 (DExD-Box Helicase 21) is a Protein Coding gene. Diseases associated with DDX21 include Stomach Disease and Retinitis Pigmentosa 33 . Among its related pathways are rRNA processing in the nucleus and cytosol and RNA Polymerase I …

Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease.

2014年11月24日 · Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells.

2024年7月15日 · DEAD-box RNA helicase 21 (DDX21) positively regulates the replication of porcine reproductive and respiratory syndrome virus via multiple mechanisms

2020年6月8日 · RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood.

2023年4月7日 · Phase-separated DDX21 highly binds on MCM5 gene locus, which is markedly reduced when phase separation is disrupted by mutations on its intrinsically disordered region (IDR). The impaired...

2020年6月8日 · RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 determined in …

2024年12月17日 · DDX21 enhances hMSMC contractility through a mechanism that involves binding to thrombospondin 1 (THBS1) mRNA, a cell adhesion molecule, and promoting its transcription and subsequent protein expression. This upregulation of THBS1 increases cellular adhesion, which is crucial for effective myometrial contraction and for contractile function.

2024年8月27日 · DDX21 orchestrates dual modes of gene regulation: unveiling its role in genetic and epigenetic control. DDX21 has multiple regulatory functions, influencing downstream gene transcription through...

DDX21, also known as nucleolar RNA helicase II, is an ATP-independent helicase associated with many nuclear and nucleolar events, such as ribosomal RNA biogenesis [158] or unwinding of R-loops [159] and RNA guanine quadruplexes [160]. DDX21 also interacts with mitotic regulator PP1 [161] and oncoprotein DEK [162].