2024年12月24日 · DNMT3B (DNA Methyltransferase 3 Beta) is a Protein Coding gene. Diseases associated with DNMT3B include Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1 and Facioscapulohumeral Muscular Dystrophy 4, Digenic .

DNMT3b plays an important role in neoplastic transformation; DNMT3B is required for the methylation of L1 CpG islands on the inactive X chromosome. Overexpression of DNMT3B is associated with breast tumor; DeltaDNMT3B is the predominant form of DNMT3B in non-small cell lung cancer.

Three DNA methyltransferase, DNMT1, DNMT3A, and DNMT3B, are the enzymatic players of DNA methylation (Leppert and Matarazzo, 2014). They cooperatively act to transfer a methyl group from S-adenosyl methionine (SAM) to the fifth carbon of cytosines (Cs).

2018年10月22日 · DNMT3B is the major de novo DNA methyltransferase expressed and active during the early stage of embryonic development, including implantation. In addition to its well-known role to methylate centromeric, pericentromeric, and subtelomeric repeats, recent observations suggest that DNMT3B acts as the main enzyme methylating intragenic regions of ...

2020年7月3日 · Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism underpinning their divergent...

2015年1月21日 · To gain insights into this matter we determined genomic binding and site-specific activity of the mammalian de novo DNA methyltransferases DNMT3A and DNMT3B. We show that both enzymes localize...

In mammals, three DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns produced through their de novo-type DNA methylation activity in implantation …

2023年1月23日 · DNA methylation is a repressive epigenetic modification that is essential for development, exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA...

2020年7月3日 · Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism underpinning their divergent genomic methylation activities.

Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated.