DJ-1 is a DNA damage response protein that is recruited to sites of DNA damage where it participates in the repair of DNA double-strand breaks through the processes of non …

DJ-1, also known as Parkinson's disease protein 7, is a multifunctional protein ubiquitously expressed in cells and tissues. Interacting with proteins of various intracellular compartments, …

DJ-1 is a small, highly conserved protein of 189 amino acids, which is ubiquitously expressed and dimeric under physiological conditions. In humans, DJ-1 is encoded by the PARK7 gene, …

2020年6月15日 · In this review, we discuss the role of DJ-1 in the physiopathology of several immune and inflammatory diseases including sepsis, allergic diseases, atherosclerosis (AS), …

DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone …

2015年4月2日 · The Parkinson’s-associated protein, DJ-1, is a highly conserved homodimer, ubiquitously expressed in cells. Here we demonstrate that DJ-1 is a 20S proteasome regulator.

2023年5月25日 · Mutations or deletions in the PARK7 / DJ-1 gene are associated with an early-onset familial form of PD. DJ-1 protein prevents neurodegeneration via its regulation of …

2023年4月18日 · This review provides an overview of the role of DJ-1 in neuroinflammation, with a special focus on its functions in microglia genetic programs and immunological traits. …

DJ-1 increases the expression of two mitochondrial uncoupling proteins (UCP 4 and UCP5), that decrease mitochondrial membrane potential and leads to the suppression of ROS production, …

2019年9月3日 · Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance …