2024年12月24日 · DDX5 (DEAD-Box Helicase 5) is a Protein Coding gene. Diseases associated with DDX5 include Lung Cancer and Cockayne Syndrome. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and SARS-CoV-2 …

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types.

2024年7月26日 · Cardiomyocyte-specific deletion of Ddx5 resulted in HF with reduced cardiac function, an enlarged heart chamber, and increased fibrosis in mice. DDX5 overexpression improved cardiac function and protected against adverse cardiac remodeling in mice with transverse aortic constriction-induced HF.

2019年5月23日 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in undifferentiated spermatogonia...

DDX5/DDX17 are coreguulators of p53, and DDX5 selectively regulates p53 mediation of growth arrest or apoptosis; DDX5 positively regulates the expression of p53 by inhibiting Δ133p53. In contrast, DDX17 negatively regulates p53 expression by inducing Mdm2 expression.

DDX5 is implicated in tumorigenesis, proliferation, metastasis and differentiation in human malignancies. Cancer-related pathways modulated by DDX5 are potential targets in cancer diagnosis, prognosis and therapy. Pre-clinical studies of …

Gene ID: 1655, updated on 4-Jan-2025. This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors.

2015年12月16日 · Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORγt partner that coordinates transcription of selective T H 17 genes, and is required for T H 17-mediated inflammatory...

Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to participate in all aspects of RNA metabolism ranging from transcription to translation, RNA decay, and miRNA processing.

2025年2月9日 · DDX5 (p68) orchestrates beta-catenin, RelA and SP1 mediated MGMT gene expression in human colon cancer cells: Implication in TMZ chemoresistance.