2024年12月24日 · DDX4 (DEAD-Box Helicase 4) is a Protein Coding gene. Diseases associated with DDX4 include Infertility and Male Infertility. Among its related pathways are Signaling by Rho GTPases and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity.

DDX4 (VASA) is an RNA helicase expressed in the germ cells of all animals. To gain greater insight into the role of this gene in mammalian germ cell development, we characterized DDX4 in both a marsupial (the tammar wallaby) and a monotreme (the platypus). DDX4 is highly conserved between eutherian, …

2023年1月18日 · DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug...

2025年2月8日 · DEAD-Box Helicase 4 (Ddx4) (+) Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers. This study clearly demonstrates that the C-terminus of DDX4 can be expressed on the cell surface despite its lack of a conventional membrane-targeting or secretory sequence. Described are adult ovarian cell populations.

2022年10月14日 · VASA, also known as DDX4, is a member of the DEAD-box proteins and an RNA binding protein with an ATP-dependent RNA helicase. The VASA gene expression, which is required for human germ cell...

DEAD-box helicase 4 (DDX4) 是一种特定的生殖细胞标志物，其表达模式定位于精母细胞和精子细胞。 在曲细精管基底膜上的SSCs中表达较低。 方法采用免疫组织化学(IHC)和Fluidigm逆转录聚合酶链反应(RT-PCR)分析DDX4在可育、不育小鼠和非梗阻性无精子症患者睾丸组织中的 ...

2024年9月30日 · ddx4的功能： ddx4在细胞增殖、分化和凋亡等方面都有重要作用。研究表明，ddx4可以影响细胞的信号传导途径，从而影响细胞的命运。此外，它还可能参与胚胎发育和器官形成等过程。 3. ddx4与疾病的关系： 一些疾病的发生与ddx4的表达水平或功能异常有关。

该基因编码 DEAD box 蛋白，它是果蝇和其他几个物种中 VASA 蛋白的同系物。 该基因在两性生殖细胞谱系中特异性表达，并在生殖细胞发育中发挥作用。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2009 年 10 月] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.

Title: Does detection of DDX4 mRNA in cell-free seminal plasma represents a reliable noninvasive germ cell marker in patients with nonobstructive azoospermia? Results suggest that DDX4 positively regulates cell cycle progression of diverse somatic-derived blood cancer cells, implying its broad contributions to the cancer cell phenotype.

在男性减数分裂I上游或内部调控蛋白质定位。位于细胞核糖核蛋白颗粒；细胞核；以及细胞质核周区域。是核糖核蛋白复合物的一部分。在消化系统肠系膜；原始生殖细胞；生殖系统；表面外胚层；以及尿生殖沟表达。与人类的DDX4（DEAD-box解旋酶4）正交。