Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. [5] It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture.

2024年12月24日 · CRYAB (Crystallin Alpha B) is a Protein Coding gene. Diseases associated with CRYAB include Cardiomyopathy, Dilated, 1Ii and Myopathy, Myofibrillar, 2. Among its related pathways are Cellular responses to stimuli and Cellular response to heat stress.

2024年9月2日 · CRYAB（Alpha B-Crystallin）是一种小分子热休克蛋白，属于小热休克蛋白（sHS. Ps）家族。 CRYAB在多种细胞类型中表达，尤其在眼睛晶状体、心脏和骨骼肌中. 表达量高。 作为一种分子伴侣，CRYAB在应激条件下发挥关键保护作用，防止蛋. 白质聚集和变性。 近年来，CRYAB在多种疾病中的作用引起了广泛关注，尤其是. 在神经退行性疾病、心肌病中的潜在应用。 本文旨在综述CRYAB蛋白的结构与功能，并探讨其在疾病中的作用机制。 CRYAB蛋 …

α-晶状体蛋白由两种基因产物组成：α-A 和 α-B，分别代表酸性和碱性。 α 晶状体蛋白可由热休克诱导，是小热休克蛋白 (HSP20) 家族的成员。 它们充当分子伴侣，尽管它们不会使蛋白质复性并以真正的伴侣的方式释放它们；相反，它们将它们保持在大的可溶性聚集体中。 这些异质聚集体由 30-40 个亚基组成； α-A 和 α-B 亚基的比例分别为 3:1。 α 晶状体蛋白的两个附加功能是自激酶活性和参与细胞内结构。 编码的蛋白质已被确定为基于其执行机械不同功能的能力的兼职蛋白 …

CRYAB is a structural protein of the lens that helps maintain lens transparency. 9 CRYAB is also expressed in non-tissue, including the heart, brain, skeletal muscle, skin, ovaries, and kidneys. 10–12 Abnormal expression of CRYAB also occurs in many diseases, such as eye diseases 58,59 and heart diseases. 60,61 There is increasing evidence that ...

2025年2月9日 · Title: CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1.

2019年5月30日 · This article reviews the regulation of CRYAB in the apoptotic inflammatory signaling pathway and its role in cancers progression and as a key role in anti-cancer therapy targeting CRYAB in an effort to improve outcomes for patients with metastatic disease.

CRYAB是小型热休克蛋白家族的成员，该家族首次发现于眼睛的晶状体中，并涉及多种疾病，例如眼和心脏病，甚至癌症，例如乳腺癌，肺癌，前列腺癌和卵巢癌。 此外，CRYAB蛋白还参与多种信号传导途径，包括细胞凋亡，炎症和氧化应激。 这篇综述总结了有关CRYAB在信号通路和疾病中的作用的最新进展。 因此，迫切需要CRYAB在信号通路和癌症中的作用。 本文综述了CRYAB在凋亡性炎症信号通路中的调控及其在癌症进展中的作用，以及在针对CRYAB的抗癌治疗中的 …

2025年3月4日 · 1 Introduction. The CRYAB gene encodes the protein Alpha-B-crystallin, or αB-crystallin, a protein belonging to the small heat shock family of proteins that has been linked to normal cardiac homeostasis as well as cardiomyopathies, among other diseases [].CRYAB, the causal gene, is 3.2 kilobases long and situated on chromosome 11 [].Although its role as a molecular chaperone for desmin is ...

索拉非尼 (sorafenib)是一种新型多靶点抗肿瘤药物,能够抑制ERK (细胞外调节蛋白激酶,extracellularregulatedproteinkinases)信号传导系统Raf、抑制血管内皮生长因子受体 (vascularendothelialgrowthfactorreceptor,VEGFR)和血小板衍生生长因子受体 (platelet-derivedgrowthfactorbetareceptor,PDGF- (3R)等酪氨酸激酶受体而抑制肿瘤进展,但其临床效果不一。 有研究提示Cryab过表达可诱导ERK1/2组成性激活及肿瘤的EMT。