CREB-TF (CREB, cAMP response element-binding protein) [1] is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. [2] CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. [3]

2020年4月28日 · Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients.

The cAMP-response element binding protein (CREB) is an intracellular protein that regulates the expression of genes that are important in dopaminergic neurons. Dopamine affects the phosphorylation of CREB via G protein-coupled receptors.

Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge.

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription …

Along with its anchoring binding partner, CREB binding protein (CBP), pCREB upregulates transcription of target genes. Transcriptional regulation through CREB has been implicated in mechanisms of cell survival, plasticity, and learning and memory paradigms.

2005年11月17日 · The cAMP response element binding protein (CREB) is a ubiquitously expressed nuclear transcription factor that is activated by various extracellular stimuli. CREB is known to regulate the expression of genes important to cell proliferation, differentiation, adaptation, and survival in many cell types.

2024年2月1日 · The cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a widely expressed, kinase inducible transcription factor, activated by growth factors, peptide hormones and calcium ions, and has a prominent role in the development and function of the CNS (Lonze and Ginty, 2002).

Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP)/beta-catenin or gamma-catenin interaction. Study indicates that BPA increases phosphorylated CREB in MCF-7 Cells as well as it binding to SOX2 enhancer.

Among these factors, the cAMP-responsive element-binding protein (CREB) has emerged as a key transcriptional element for the maintenance of an efficient glucose sensing, insulin exocytosis, insulin gene transcription and β-cell survival.