2016年4月5日 · Here, we demonstrate that this adaptation is driven by the ratio of reduced to oxidized CoQ. Saturation of CoQ oxidation capacity induces reverse electron transport from reduced CoQ to complex I, and the resulting local generation of superoxide oxidizes specific complex I proteins, triggering their degradation and the disintegration of the complex.

2021年5月12日 · 本研究发现, 除了合成嘧啶核苷酸, DHODH还可以通过产生线粒体内膜中CoQH2从而在线粒体中抑制铁死亡, 这是因为CoQH2可以作为一种自由基捕获型抗氧化剂（radical trapping antioxidant）来阻止脂质过氧化，从而抑制铁死亡。

2016年4月5日 · Here, we demonstrate that this adaptation is driven by the ratio of reduced to oxidized CoQ. Saturation of CoQ oxidation capacity induces reverse electron transport from reduced CoQ to complex I, and the resulting local generation of superoxide oxidizes specific complex I proteins, triggering their degradation and the disintegration of the complex.

1992年6月26日 · Ubiquinol-10 (CoQH2, the reduced form of coenzyme Q10) is a potent antioxidant present in human low-density lipoprotein (LDL). Supplementation of humans with ubiquinone-10 (CoQ, the oxidized coenzyme) increased the concentrations of CoQH2 in plasma and in all of its lipoproteins.

2016年4月5日 · Guara ́ s et al. show how the mitochondrial electron transport chain (mtETC) is optimized to better oxidize different nutrients or fuels using the reducing status of ubiquinone as a metabolic sensor and ROS generated by complex I by reverse electron transport as an executor.

2023年9月4日 · Coenzyme Q, also known as ubiquinone (CoQ), is made up of quinone and a hydrophobic tail. Its purpose is to function as an electron carrier and transfer electrons to complex III. Coenzyme Q undergoes reduction to semiquinone (partially reduced, radical form CoQH-) and ubiquinol (fully reduced CoQH2) through the Q cycle.

Our findings go along with the biochemical description of CoQ10 and CoQH2, recording cardiovascular benefits for CoQ10 and antioxidative and anti-inflammatory properties for CoQH2. Our main outcomes are the following: (I) CoQ10 supplementation reduced cardiovascular death in patients with heart failure. This is not reported for CoQH2.

To prevent this, the mETC superstructure can be reconfigured through the degradation of respiratory complex I, liberating associated complex III to increase electron flux via FAD at the expense of NAD. Here, we demonstrate that this adaptation …

Ubiquinol (CoQH2) is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human low-density lipoprotein (LDL).

2016年4月5日 · By genetic modulation of interactions between complexes I and III andIII and IV, it is shown that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.

2016年3月1日 · Here, we demonstrate that this adaptation is driven by the ratio of reduced to oxidized CoQ. Saturation of CoQ oxidation capacity induces reverse electron transport from reduced CoQ to complex I,...

2011年4月9日 · Buy Solaray Ubiquinol CoQ-10 100 mg - CoQH2, Reduced CoQ10 for Enhanced Absorption - Energy and Heart Health Support - 60-Day Guarantee - 30 Servings, 30 Softgels on Amazon.com FREE SHIPPING on qualified orders

2016年4月5日 · Here, we demonstrate that this adaptation is driven by the ratio of reduced to oxidized CoQ. Saturation of CoQ oxidation capacity induces reverse electron transport from reduced CoQ to complex I, and the resulting local generation of superoxide oxidizes specific complex I proteins, triggering their degradation and the disintegration of the complex.

NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis

Mitochondrial Cys-thiol redox status was studied by the GELSILOX method (Martínez-Acedo et al., 2012). The resulting tryptic peptide mixtures were subjected to nano-liquid chromatography coupled to mass spectrometry using a data-independent scanning (DiS) method.

2024年9月21日 · In contrast to CoQ10, no CoQH2 study could clearly demonstrate a reduced cardiovascular mortality; (III) the used concentrations are much higher in studies investigating CoQH2. According to these results, we conclude that based on the medical data available, CoQ10 is the more promising supplement to prevent cardiovascular diseases and to treat ...

Recently, it has been proposed that coenzyme Q contributes to suppressing ferroptosis, a type of iron-dependent programmed cell death characterized by lipid peroxidation. In this review, we report the latest hypotheses and theories analyzing the multiple functions of coenzyme Q.

To prevent this, the mETC superstructure can be reconfigured through the degradation of respiratory complex I, liberating associated complex III to increase electron flux via FAD at the expense of NAD. Here, we demonstrate that this adaptation …

3 天之前 · CoQ and CoQH2 analysis of A549 cells 72 h after transfection with siRNAs, n = 3 independent samples (g). NADH consumption assay (A340 nm) in TBS buffer containing different concentrations of CoQ10 ...

Despite the lack of detectable hydrogen peroxide production, up-regulation of the levels of mitochondrial antioxidant defenses revealed a significant redox unbalance.