CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. [5][6][7][8] It is a subunit of the CCR4-Not deadenylase complex. The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation.

2024年12月24日 · CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene expression (Transcription) and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.

2025年2月8日 · CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway. Data show that incorporation of ATP-dependent RNA helicase eIF4A-2 (eIF4A2) into the CCR4-NOT complex inhibits CCR4-NOT transcription complex subunit 7 …

In this study, we addressed the contribution of CNOT7/8 to viability of primary mouse embryonic fibroblasts (MEFs). We found that MEFs lacking CNOT7/8 expression [Cnot7/8-double knockout (dKO) MEFs] undergo cell death, whereas MEFs lacking CNOT6/6L expression (Cnot6/6l-dKO MEFs) remain viable.

To examine whether CNOT7/8 catalytic activity is critically involved in MEF viability, we introduced either FLAG epitope-tagged CNOT7-WT or CNOT7 mutants into Cnot7/8-dKO MEFs, using a recombinant retrovirus.

2020年5月20日 · CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma. Ren C, Ren X, Cao D, Zhao H, Zhai Z, Li H, Li Y, Fu X, He J, Zhao HRen C, et al. FEBS Open Bio, 2020 May. PMID 32160402. CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease.

2022年5月15日 · Depletion of CNOT7 increased CNOT8 incorporation into the CCR4-NOT complex and stabilized CNOT8. These data suggest that CNOT7 is the dominant paralog in CCR4-NOT and that CNOT7 and CNOT8 protein stability is regulated in distinct ways.

2024年11月27日 · Title: CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway. Data show that incorporation of ATP-dependent RNA helicase eIF4A-2 (eIF4A2) into the CCR4-NOT complex inhibits CCR4-NOT transcription complex subunit 7 (CNOT7) deadenylation activity.

McFleder et al. find that CNOT7, the major deadenylase in eukaryotes, has a specialized role in neurons. CNOT7 regulates the dendritic localization and translation of specific mRNAs and mediates synaptic plasticity and learning and memory in mice.

2024年7月10日 · The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an important functional subunit of CCR4-NOT protein complex that has not been reported in glioma. In this study, we aimed to explore the function of CNOT7 in glioma.