The serine/threonine kinase CHK2 is a key component of the DNA damage response. In human cells, following genotoxic stress, CHK2 is activated and phosphorylates >20 proteins to induce the appropriate cellular response, which, depending on the extent of damage, the cell type, and other factors, could be cell cycle checkpoint activation ...

2024年12月24日 · CHEK2 (Checkpoint Kinase 2) is a Protein Coding gene. Diseases associated with CHEK2 include Tumor Predisposition Syndrome 4 and Prostate Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the induction of cell cycle arrest and apoptosis by DNA damage. Insight into Chk2 has derived from multiple approaches. Biochemical studies have addressed Chk2 structure, domain organization and regulation by phosp …

In addition, suppressing DNA damage and replication checkpoint responses by inhibiting Chk1 can enhance tumor cell killing by diverse genotoxic agents. Here, we review current understanding of the organization and functions of the ATM-Chk2 and ATR-Chk1 pathways and the prospects for targeting DNA damage signaling processes for therapeutic purposes.

CHK2蛋白激酶是DNA损伤检查点信号的重要转导者，其突变有助于遗传和散发性癌症。 DNA损伤激活的ATM激酶使Thr68磷酸化，从而触发CHK2激活。 这导致瞬时的CHK2二聚化，部分地是通过分子间的磷酸化Thr68-FHA结构域相互作用。 二聚化通过活化环自磷酸化促进激酶活化，但是该过程的机制尚不清楚。 本文所述的CHK2的二聚体晶体结构，结合生化和突变数据揭示，生产性CHK2二聚化还涉及分子间FHA激酶结构域和FHA-FHA相互作用。 在Li-Fraumeni癌症易感综 …

CHK2 is a versatile and multifunctional kinase that regulates the cell's response to DNA damage by phosphorylating a number of distinct cellular substrates. CHK2 can prevent tumour progression...

2009年9月24日 · The CHK2 protein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contributes to hereditary and sporadic cancer. CHK2 activation is triggered by the phosphorylation of Thr68 by the DNA damage-activated ATM kinase.

2001年12月1日 · Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic...

Chk2已被证实是一种肿瘤抑制因子，并且在一些癌症中发生突变或减少，包括乳腺癌、结肠癌、膀胱癌、卵巢癌和前列腺癌。Chk2的低表达或缺失对肿瘤有保护作用，可能与肿瘤的发生发展相关。

Checkpoint kinase 2 (Chk2，又被称作hCds1或Chek2)是一种多功能蛋白激酶，作为肿瘤抑制基因，在多种肿瘤中发现其发生突变，包括肝癌、乳腺癌、卵巢癌、膀胱癌、前列腺癌和结肠癌等[1,2]。Chk2作为DNA损伤应答信号通路中的重要一员，在DNA损伤反应中发挥着重要作用。