Pharmacogenetics of Complement Factor H Y402H Polymorphism …
2015年9月28日 · Indeed, as our analysis demonstrates, 41.3% of patients harboring a homozygous risk allele genotype (CC) at the CFH Y402H locus showed good response with …
Loss of Complement Factor H impairs antioxidant capacity and …
2020年6月25日 · Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD …
Human complement factor H Y402H polymorphism causes an age …
2019年2月11日 · We show that aged mice expressing the human H402, but not Y402 variant, (i) develop AMD-like symptoms and (ii) display differences in their systemic and ocular lipoprotein …
Complement factor H Y402H polymorphism results in diminishing …
2023年11月8日 · Genetic variants in the gene encoding complement factor H (CFH) have been identified as an AMD susceptibility gene, however, the mechanistic link is debated. Here, we …
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Complement factor H related proteins (CFHRs) - ScienceDirect
2013年12月15日 · Genetic abnormalities within the CFHR gene locus can result in hybrid proteins with affected dimerization or recognition domains which cause defective functions. Here we …
Complement Factor H: Spatial and Temporal Expression and Localization ...
Complement factor H (CFH) is a component of the mammalian complement system, which regulates the alternative pathway of complement activation and protects the host cell from …
Variants in Complement Factor H and Complement Factor H …
2014年9月9日 · Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1–5, with …
CFH complement factor H - NIH Genetic Testing Registry (GTR)
2024年9月18日 · Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Genome-wide association study of …
Complement factor H variants are associated with …
We perform a study to investigate the CFH /CFHRs gene variants and their roles in IgAN with microangiopathy based on a previous genome-wide association study (GWAS). Methods: We …