Cdk5 is a proline-directed serine/threonine kinase, which was first identified as a CDK family member due to its similar structure to CDC2/CDK1 in humans, a protein that plays a crucial role in the regulation of the cell cycle.

Ckd5是作为一种多功能激酶，其主要功能是参与神经细胞迁移、轴突导向、突触发生与传递，近年来研究发现，CDK5在多种组织中表达，它可以通过磷酸化不同的调节底物发挥多种生物学作用。

2024年12月24日 · CDK5 (Cyclin Dependent Kinase 5) is a Protein Coding gene. Diseases associated with CDK5 include Lissencephaly 7 With Cerebellar Hypoplasia and Lissencephaly. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Gene expression (Transcription).

2024年9月4日 · CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392.

The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The activation of CDK5 is dependent on interaction with its activator ...

2001年10月1日 · Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system.

2025年1月21日 · This review explores the structure and biological functions of CDK5, highlighting its regulatory roles in disease development through the phosphorylation of diverse substrate proteins. Additionally, we examine the therapeutic potential of CDK5 inhibition, offering novel perspectives for disease diagnosis and treatment.

2019年11月6日 · Treatment with the CDK5 inhibitor roscovitine sensitizes cells to heat-induced apoptosis and its phosphorylation, which results in prevention of the apoptotic protein functions. Here, we highlight the regulatory mechanisms of CDK5 and its roles in cellular processes such as gene regulation, cell survival, and apoptosis.

2011年12月20日 · Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an array of neurodegenerative diseases.

2024年11月15日 · 最新研究证明，CDK5的抑制剂如CDK5抑制肽（CDK5 inhibitory peptide，CIP）、萝卜硫素（sulforaphene，SF）能够破坏CDK5和p25之间的相互作用，抑制CDK5/p25复合物的活性，减少Tau蛋白的过度磷酸化，从而有效预防AD的发生发 展 [