2014年2月10日 · CD49d emerged as the strongest flow cytometry–based prognostic marker, with greater prognostic value than CD38 and ZAP-70. Using a training/validation strategy, we established the 30% cut point as the most useful threshold for classification of CD49d+ CLL.

CD49d is a surface subunit of the integrin heterodimer that is involved in promoting survival of the CLL cells through microenvironment derived growth signals. CD49d can be used as a reliable predictive marker of aggressive disease course and inferior survival is associated with ≥30% cells expressing CD49d by flow cytometry.

2010年7月1日 · We found CD49d (VLA4), a member of the integrin α-chain family of proteins, to be exclusively expressed on CD11b + Gr-1 dull/int cells. CD49d is composed of a α4 (CD49d) and a β1 (CD29) chain and serves as a receptor for fibronectin and VCAM-1 (VCAM-1, CD106).

2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression.

We confirm that CD49d is predictive for time to first treatment (P<0.0001) and overall survival (P<0.0001) and increases the prognostic power of CD38, ZAP-70 and IGHV gene mutation status in concordant cases. Furthermore, CD49d retained independent prognostic significance in multivariate analysis.

Multivariate analysis, controlling for disease stage, ZAP-70, IGHV status and fluorescent in situ hybridization defects identified CD49d as an independent predictor of OS and was a better predictor of clinical outcome than ZAP-70, IGHV, or cytogenetics.

A more recently discovered marker is CD49d, the alpha4 subunit of the VLA-4 integrin (alpha4beta1). High CD49d expression predicts reduced overall survival and time to first treatment in CLL patients [10, 11].

2016年4月25日 · CD49d, the alpha-chain of the integrin heterodimer α4β1, was identified among the strongest predictors of overall survival (OS) in chronic lymphocytic leukemia (CLL), along with IGHV...

2025年3月18日 · Projecting the expression of markers throughout differentiation, we found that CD105 had a greater dynamic range in the early stages (ProE to LB) compared to CD49d, while CD49d exhibited greater dynamic range during the terminal stages (PolyE and OrthoE/Retics) (Figure 1D). Indeed, CD105 expression discriminated three groups during the first ...

2010年7月1日 · In this study, through gene-expression analysis, we have identified a new marker, CD49d, which is expressed exclusively on CD11b(+)Gr-1(dull/int.) MDSCs. We have characterized two subpopulations of MDSCs based on CD49d expression in two different settings, a mouse model of inflammatory bowel disease and tumor-bearing mice.