Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD 41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

2001年4月1日 · To investigate the precise expression of the CD41 antigen during megakaryocyte (MK) differentiation, CD34 + cells from cord blood and mobilized blood cells from adults were grown for 6 days in the presence of stem cell factor and thrombopoietin. Two different pathways of differentiation were observed: one in the adult and one in the neonate cells.

Invitrogen Anti-CD41a Monoclonal (HIP8), eBioscience™, Catalog # 14-0419-82. Tested in Immunohistochemistry (IHC) and Flow Cytometry (Flow) applications. This antibody reacts with Human samples.

2011年5月12日 · CD41 expression is associated with the earliest stages of mouse hematopoiesis. It is notably expressed on some cells of the intra-aortic hematopoietic clusters, an area where the first adult-repopulating hematopoietic stem cells (HSCs) are generated.

Glanzmann thrombasthenia (GT) is a rare autosomal recessively inherited bleeding disorder characterized by the quantitative (type 1 and type 2) or qualitative (type 3) deficiency in platelet membrane glycoprotein (GP) IIb/IIIa (CD41a/CD61) fibrinogen receptors. In type 1, 2, and 3, CD41a/CD61 expression is 5%, 5%–20% and above 20%, respectively.

The CD41 antigen (platelet GPIIb; IIb integrin) is a transmembrane glycoprotein composed of two chains GPIIbα (120 kDa) and GPIIbβ (23 kDa) linked by one disulfide bond. CD41 is always non-covalently associated with CD61 (platelet GPIIIa, β3 integrin), to …

2013年5月30日 · Integrin CD41, thought to absent on adult HSCs, marks a novel subset of myeloid-biased long-term HSCs that becomes prevalent with age. Loss of CD41 leads to transplantable hematopoietic defects that affect HSC survival and maintenance and are, in part, mediated by platelet loss.

2025年2月13日 · We investigated interactions with CD41a-expressing EVs and the resulting cell activation in CD4 + TLs, monocytes, and BLs cultured for 18 h in the presence or absence of purified CD41a + EVs at a ratio of 1:20 (cells: EVs).

Flow cytometric analysis of CD41a expression on human peripheral blood platelets. Platelets were stained with either PE Mouse IgG1, κ Isotype Control (Cat. No. 555749; dashed line histogram) or PE Mouse Anti-Human CD41a (Cat. No. …

The commonly used term CD41a refers to the platelet glycoprotein IIb/IIIa platelet membrane adhesive protein receptor complex, consisting of integrin-alpha-2b (alpha subunit), and the beta subunit, ... ... ... ...