CD40 is a potent stimulator of the immune system and, as such, CD40/CD40L interaction on immune cells has been extensively studied for its involvement in the development of protective …

CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue …

2024年12月24日 · CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Agammaglobulinemia, X-Linked. …

2023年2月23日 · Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of …

CD40 is a 48 kilodalton transmembrane glycoprotein surface receptor that is a member of the Tumor Necrosis Factor Receptor superfamily (TNFRSF). The importance of CD40 in …

6 天之前 · Without proper CD40-CD40L engagement, germinal center responses are impaired, weakening long-term humoral immunity. CD40 signaling also influences whether B cells …

2019年2月15日 · Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal …

This article reviews recent developments in this field of research, with main emphasis on (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro …

2008年11月1日 · CD40 has a rich history as a prominent immune cell activator. 1 CD40 is best known as the key mediator of B lymphocyte immunoglobulin class switch. It also serves as a …

2019年2月7日 · CD40 is constitutively expressed on APCs such as B cells and dendritic cells. It is also expressed on other hematopoietic cells including T cells and macrophages after cellular …