CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1]

What is the CD3 Marker? The CD3 marker is a protein complex found on the surface of T lymphocytes, a type of white blood cell that plays a pivotal role in the immune system. It consists of several proteins, most notably the CD3 epsilon, CD3 gamma, CD3 delta, and CD3 zeta chains.

2022年3月18日 · CD8 marks reactive cytotoxic T cells. TFH markers (PD-1, ICOS, BCL6, CD10, CXCR13) remain negative. The tumor cells coexpress TBX21 / T bet and CXCR3 but remain negative in GATA3 and CCR4 (Blood 2019;134:2159). The image shows the typical membranous staining pattern for CD3 in mature T cells.

CD3 is an essential T cell co-receptorand defines T cell lineage. CD3is therefore an ideal T cell marker. This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

2020年11月13日 · A distinct subset known as tissue-resident memory cells (Trm) are described as non-circulating and can be identified by the markers CD69, ITGAE (CD103) and CTLA4 (CD152). It is important to note that markers can be detected on more than one cell type, but at varying expression levels.

Absolute CD3 cells, also known as CD3+ cells, refer to a subset of T-lymphocytes that express the CD3 marker on their surface. CD3 is a protein complex and T cell co-receptor involved in activating both cytotoxic T cells (CD8+ naive T cells) and T helper cells (CD4+ naive T cells).

2018年7月30日 · CD markers are mostly useful for classifying white blood cells (WBC) and especially important for the diagnosis of lymphomas and leukemias. The popular CD markers are CD138 , which is expressed on multiple myeloma cells; CD33 expressed on cells of myeloid lineage; and CD52 , which is expressed at high density by lymphocytes, monocytes ...

2023年7月7日 · CD markers are not only important in the diagnosis of cancer, but they can also help identify which types of treatment may be most successful and measure how effective the treatment is by monitoring changes in the relevant CD markers.

2024年6月7日 · CD3 is a pivotal component of the immune system, playing a crucial role in the activation and function of T cells. Its importance in immune signaling and regulation makes it a key target for therapeutic interventions and a valuable marker in clinical diagnostics.

2025年3月19日 · Since CD3 is present on all mature T cells, including CD4+ helper T cells and CD8+ cytotoxic T cells, it serves as a universal marker for identifying and quantifying T cell populations. Flow cytometry, a widely used immunological technique, relies on CD3 expression to distinguish T cells from other lymphocytes like B cells and natural killer ...