Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene. [5] . CD24 is a cell adhesion molecule. CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts.

2024年12月24日 · CD24 (CD24 Molecule) is a Protein Coding gene. Diseases associated with CD24 include Erythroleukemia and Multiple Sclerosis. Among its related pathways are Nervous system development and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and carbohydrate binding.

2025年2月8日 · Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and carbohydrate binding activity. Involved in several processes, including chemokine receptor transport out of membrane raft; negative regulation of cytokine production; and regulation of inflammatory response to wounding.

2019年8月5日 · CD24，全称为cluster of differentiation 24，又称热稳定抗原，是一种高度糖基化的糖基磷脂酰肌醇锚定表面蛋白，已知与先天免疫细胞上的 Siglec-10 （sialic-acid-binding Ig-like lectin10）相互作用，以抑制响应感染、败血症、肝损伤和慢性移植物抗宿主疾病的破坏性炎症反应。 然而，也有研究显示， CD24表达于多种实体肿瘤 [4-5]，但该分子在调节肿瘤免疫反应中的作用尚未被证实。 CD24直接保护癌细胞不被巨噬细胞吞噬（图片来源：Nature） 这项新研究证 …

1978年，科学家首次发现CD24，即分化簇24（Cluster of differentiation 24），也称为热稳定抗原（heat-stable antigen，HSA)，一种高度糖基化的糖基磷脂酰肌醇 (GPI)锚定的膜蛋白。 CD24没有胞内信号结构域，然而，几种信号转导蛋白与CD24活性相关，其中研究最充分的是 Src家族激酶。 CD24信号可影响细胞的增殖和生长，也可通过影响细胞间黏附作用进而促进肿瘤的侵袭和转移。

2019年7月31日 · We demonstrate a role for tumour-expressed CD24 in promoting immune evasion through its interaction with the inhibitory receptor sialic-acid-binding Ig-like lectin 10 (Siglec-10), which is...

2025年2月8日 · Findings indicate that CD24 (+) antigen cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer. CD24 is a conserved marker for tracking divergent states in both reprogramming and standard pluripotent culture.

该基因的人类正链同系物与多发性硬化症有关。 与人类CD24（CD24分子）正链同系物同源。 [由基因组资源联盟，2022年4月提供]

The human CD24, homologous to the mouse CD24a or heat-stable antigen (HSA), is an important protein anchored to the membrane by glycosyl-phosphatidyl-inositol (GPI). CD24 is widely used as a marker for differentiation of multiple lineages of cells ( for example, T cells and B cells), and can adapt the immune response.

CD24A is the predominant CD24 isoform in HCC and plays a major role in cell proliferation, migration, and invasion. EGR1 can exert its antitumor effect through transcriptional downregulation of CD24A in HCC. Keywords: CD24A, …