CD31又称为血小板-内皮细胞黏附分子（Platelet endothelial cell adhesion molecule-1 ，PECAM-1/CD31），分子量为130kDa，其结构属于免疫球蛋白超家族成员，在清除体内老化的中性粒细胞过程中发挥重要作用。

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. [5] [6] [7] [8] PECAM-1 plays a key role …

CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1), is a single chain 130 kDa glycoprotein consisting of 6 Ig-like extracellular domains, a short transmembrane segment and a cytoplasmic tail containing two ITIMs (ImmunoTyrosine Inhibitory Motif).

CD31 是一种促进白细胞跨内皮迁移的细胞粘附分子。 CD31-CD31 的嗜同性相互作用决定了CD31的大部分生物学功能。 CD31与CD177的嗜异性相互作用促进中性粒细胞的跨内皮迁移。 CD31可以通过嗜同性跨内皮相互作用参与细胞粘附。 fMLP或CXCL8/IL-8刺激可下调嗜中性粒细胞细胞表面CD31的表达。 在血小板和白细胞上表达，主要集中在内皮细胞边界。 表达于人脐静脉内皮细胞 (HUVECs) (蛋白水平)。 中性粒细胞 (蛋白水平)表达。 异构体1在所有检测的组织中表 …

本文就CD31的定义、结构、共受体、功能、信号通路及相关疾病进行简单介绍。 1. 什么是CD31？ CD31是是由位于17号染色体长臂末端的75kb基因编码的跨膜糖蛋白。CD31最早是Newman及其同事于1990年发表于Science上的一篇报告中提出。

CD31, or PECAM-1 (platelet endothelial adhesion molecule), is a cell-cell adhesion and signaling protein with established roles in immune cell transmigration and angiogenesis.

Breast ductal carcinoma in situ is an intraductal proliferation of malignant epithelial cells that diffuse within the ductal system without stromal invasion. Our finding that a subset of these tumors express CD31/platelet endothelial cell adhesion ...

2012年2月29日 · CD31 is a 130 kDa platelet–endothelial cell (EC) adhesion molecule that was initially identified from ECs and platelets 1 and later from blood leucocytes. 2 Mature CD31 contains a short [22-amino acid (aa)] NH 2-terminal peptide followed by six C2-type immunoglobulin (Ig) domains, each flanked by two conserved cysteine residues outside the ...

CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed constitutively on the surface of adult and embryonic endothelial cells and is also expressed on many peripheral leukocytes and platelets.

分化群31(cd31)，又名血小板内皮细胞粘附分子(pecam-1)，在清除机体老化的中性粒细胞过程中起关键作用。 cd31存在于血小板、单核细胞、中性粒细胞和某些类型的t细胞表面。