In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. [5] Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers , which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in ...

CD18 is a 95 kDa glycoprotein that is a subunit of LFA-1. It consists of extracellular, transmembrane, and cytoplasmic domains, with potential glycosylation sites and cysteines for structural stability.

2005年12月15日 · Using CD18 −/− mice, we demonstrate that CD18 is necessary for the development of optimal numbers of both innate and peripherally induced CD4 + CD25 + Treg cells, as well as for the suppressor function of these cells. Consistent with these defects is the development of autoantibodies, indicating a propensity to autoimmunity in the absence of CD18.

整联蛋白β-2（英語： Integrin beta-2 ，CD18）是一个由人类基因 ITGB2 编码的蛋白质，是整联蛋白的一种β亚基。 能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：

设立分化簇 (CD) 命名系统的目的是对白细胞表面抗原进行分类。 最初，表面抗原是根据与它们结合的对应单克隆抗体进行命名。 随着各实验室逐渐发现抗原常能刺激产生多种单克隆抗体，因此需要采用一种统一的命名系统。 1982 年于巴黎举行的第 1 届国际人类白细胞分化抗原专题讨论会 (HLDA) 上通过了目前使用的命名系统。 根据该命名系统，已经充分表征的抗原将会分配数字（例如，CD1、CD2 等），而对于仅有一种单克隆抗体可以识别的抗原分子，则分配临时名 …

2019年4月9日 · Precise spatiotemporal regulation of leukocyte extravasation is key for generating an efficient immune response to injury or infection. The integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18)...

CD18 deficiency leads to neutrophilia and myeloid hyperplasia in the bone marrow (BM). These studies examined the role of CD18 in regulating neutrophil production and determined whether the defects in neutrophil production that are observed in CD18 deficiency persist in the presence of wild type (WT) leukocytes that confer host protection.

2021年11月7日 · CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation.

整联蛋白β-2 （英语： Integrin beta-2 ， CD18 ）是一个由人类 基因 ITGB2 编码的 蛋白质 ，是整联蛋白的一种β亚基。 能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：

CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration - two key aspects for localizing peripheral leukocytes to sites of inflammation.