
CD11 - an overview | ScienceDirect Topics
3.2.4 CD11b protein. The CD11b protein (also known as integrin α-M, CD11b/CD18, MO1 or Mac-1) is a component of complement receptor 3. 51 This protein is expressed in immune cells, where it mediates many functions, including cell adhesion, migration and phagocytosis. 52 The clone 42 of the specific mouse antibody against rat CD11 protein, known as OX-42, is used for …
CD11 - an overview | ScienceDirect Topics
2010年2月1日 · BCL-1 (cyclin D1) is a proto-oncogene involved in regulation of the cell cycle. Rearrangement of this gene as seen in 1(11,14)(q13:q32) is associated with certain B-cell lymphomas, such as mantle cell lymphoma and a subclass of plasma-cell myeloma with overexpression of BCL-1 protein in these tumors.
CD11 - an overview | ScienceDirect Topics
Because the CD40–CD40L interaction can be antagonized with mAbs against either CD40L or CD40, antagonizing CD40 seems a more attractive approach. A blocking anti-CD40 mAb has shown promising results in a small open label phase I/IIa study in CD patients without serious side effects [54]. The therapeutic benefit by antagonizing CD40 may ...
CD11c - an overview | ScienceDirect Topics
The leukocyte integrin CD11c is a myeloid marker expressed on most DCs (Table 1).CD11c + DCs can be further subdivided by their expression of CD8α, the alpha chain of the T-cell co-receptor CD8 (see [2] for a recent review of DCs).
CD11b Antigen - an overview | ScienceDirect Topics
By contrast, in the mouse, long-term repopulating activity is present in the CD34 −/low fraction but not in the CD34 + fraction of adult bone marrow cells. 3 HSCs in the aorta–gonads–mesonephros region and fetal liver are, however, known to express CD34 antigen. 10, 11 Therefore, the expression of CD34 antigen on HSCs is developmentally ...
CD11c - an overview | ScienceDirect Topics
CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
CD11a - an overview | ScienceDirect Topics
In B and T cells, all CD11/CD18-dependent functions – such as mitogen, antigen, and alloantigen-induced proliferation, T cell-mediated cytotoxicity, B cell aggregation, and Ig production – are inhibited by anti-LFA-1 mAbs.
CD11a - an overview | ScienceDirect Topics
Anti-adhesion antibodies. Russell L Dedrick, ... Marvin Garovoy, in Transplant Immunology, 2002. CD11a is an attractive therapeutic target for T cell-mediated disorders because of its key roles in: (1) binding to inflamed vascular endothelium; (2) trafficking through the endothelial layer into underlying tissue; and (3) adhesion and co-stimulatory interactions with antigen presenting cells.
[11] Calculation of protein conformation from circular dichroism
1986年1月1日 · This chapter discusses some recent developments in the estimation of various conformations in a protein molecule from its circular dichroism (CD) spectrum in the ultraviolet region. Optical rotatory dispersion (ORD) and CD are two chiroptical phenomena, which differentiate two enantiomers.
Effects of seed priming with different concentrations and forms of ...
2025年3月1日 · The reduction in MDA levels in the 500-IS-Cd, 1000-IS-Cd, 11.6-OS-Cd, and 58-OS-Cd treatment groups compared to the CK-Cd group strongly supports this mechanism. Si may also promote Cd sequestration in the root zone, which could limit the transport of Cd to the shoots, reducing its toxic effects on shoot and bud tissues.