Calu-3 is a non-small-cell lung cancer cell line that grows in adherent culture and displays epithelial morphology. These cells have constitutively active ErbB2/Her2 due to amplification of the ERBB2 gene.

2020年10月22日 · Calu-3 cells are a submucosal gland cell line, which was generated from a bronchial adenocarcinoma. Under air–liquid interface conditions Calu-3 cells grow in monolayers, producing mucus and cilia-like microvilli.

This article reviews the application of the human airway Calu-3 cell line as a respiratory model for studying the effects of gas concentrations, exposure time, biophysical stress, and biological agents on human airway epithelial cells.

Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl-secretion. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Calu-3 cells constitute a human-derived airway epithelial cell line representing non-small cell lung carcinoma. They are widely used in biomedical research that includes studying lung cancer biology, respiratory diseases, host-pathogen interactions, and drug transport in the airway.

Calu-3 are more readily available than NHBE cells, polarize into stable cultures more rapidly than NHBE cells, and demonstrate restricted, persistent infection and directional viral maturation similar to NHBE cultures, demonstrating that Calu-3 are a useful in vitro model of polarized human lung epithelium-derived cells for studying cellular ...

The Calu-3 tumor model is a well-established xenograft model to study the effects therapeutics, such as erlotinib, trastuzumab and pertuzumab on HER2 and EGFR expressing cells. Calu-3 xenografts are commonly used to investigate the effects of various drugs and compounds on tumor growth and metastasis.

Calu-3细胞是从一名25岁的白人男性肺腺癌患者的胸水中分离建系的；该患者曾使用过环磷酰胺、博来霉素、阿霉素进行治疗。 Calu-3细胞接种至裸鼠可成瘤；Calu-3细胞亦可作转染宿主。

In this study, we report differences in response of Calu-3 epithelial cells to exogenous stimuli Staphylococcus aureus enterotoxin B (SEB) and house dust mite (HDM) extract compared to primary nasal epithelial cells.

The Calu-3 cell line can assist in finding potential drug therapies and has shown to be useful in mimicking in vivo conditions.3 This similarity has allowed for many pharmaceutical applications such as drug transport, studying aerosol deposition, controlled release studies, and identification of potential drug-drug interactions.4 The ...